Scanning Platform Provides Management and Analysis of Digital Pathology Images

A scanning platform processes batches of slides using both brightfield and multichannel fluorescence providing a solution for digital pathology scanning.

The platform offers monochrome detectors for fluorescence, which provide excellent separation of individual fluorophores that may be close in wavelength, while color detectors for brightfield provide excellent digital slide capture quality.


The SCN400 2.2 by Leica Microsystems (Wetzlar, Germany) can handle up to five fluorescence channels per slide, providing a truly flexible whole slide scanning solution.

Multiple markers are captured on a single sample, with clear focus and channel separation, ensuring that scientists maximize results from precious or rare samples. Capacity for multiple filter cubes enables up to seven distinct fluorescence channels to be utilized across a scanning batch, providing flexibility for the varied samples in various laboratories.

The advanced tissue finding system automatically identifies areas for capture for brightfield imaging. Leica’s Dynamic Focus saves the overhead cost of slide premapping, rapidly scanning high quality whole slide images. The addition of the SL801 autoloader with capacity for 384 slides makes the SCN400 2.2 a fully automated, high-throughput system.

Dr. Donal O’Shea, head of digital pathology at Leica Microsystems, said that the advanced brightfield and fluorescence imaging capacity provides an optimal single-platform scanner for the varied samples used by biomarker discovery and translational scientists.

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