We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

LabMedica

Download Mobile App
Recent News Expo Clinical Chem. Molecular Diagnostics Hematology Immunology Microbiology Pathology Technology Industry Focus

CELLAVISION AB

Cepheid's Multi-Target Test Design Enables Detection of Influenza Variants

By LabMedica International staff writers
Posted on 09 Dec 2022

Variants of the (H1N1)pdm09 and A(H3N2) viruses containing matrix gene mutations are currently circulating around the world. The two recently identified mutations in the matrix genes of the Human Influenza A virus have been reported to cause matrix gene target failure (MGTF) for several commercial diagnostic tests. Recombination and other mutations of the viruses impact the performance of molecular diagnostic tests – which may lead to an increase in false negative test results. The greatest impact occurs in tests that detect only one genetic target of the influenza genome. The currently circulating mutant strains of influenza highlight the need for multi-target diagnostic tests.

Cepheid’s (Sunnyvale, CA, USA) respiratory test design enables detection of these new variants, and with similar symptoms across various illnesses such as the flu, respiratory syncytial virus (RSV) disease, and COVID-19, when accurate and fast diagnosis is critical to patient care. Cepheid's respiratory tests, the Xpert Xpress Flu/RSV, Xpert Xpress SARS-CoV-2/Flu/RSV and Xpert Xpress CoV-2/Flu/RSV plus, all utilize a multi-target approach for the detection of influenza, providing target redundancy to mitigate the potential impact of genetic shift and drift on strain detection.


Image: Xpert Xpress CoV-2/Flu/RSV plus enables actionable, rapid respiratory results (Photo courtesy of Cepheid)
Image: Xpert Xpress CoV-2/Flu/RSV plus enables actionable, rapid respiratory results (Photo courtesy of Cepheid)

"In developing our portfolio of respiratory tests, we include multiple conserved gene targets to account for genetic drift within the influenza genome," said David Persing, M.D., Ph.D., EVP and Chief Scientific Officer of Cepheid. "The resulting target redundancy mitigates the impact of mutational drift. Our three-gene target design for detection of influenza A reduces the risk of false-negative test results, even in the event of an MGTF."

"The Medicines and Healthcare Products Regulatory Agency (MHRA), United Kingdom (UK) has asked all influenza test manufacturers in the UK to analyze their tests for any impact to diagnostic performance against the H1N1pdm09 strain. Our Scientific Affairs team performed in silico testing of the performance of our portfolio of influenza tests against the new H1N1pdm09 strain," said Mike Loeffelholz, Ph.D., D(ABMM) and Senior Director, Scientific Affairs. "Our analysis shows 100% predicted coverage for this strain."

Related Links:
Cepheid 


New
Platinum Member
Flu SARS-CoV-2 Combo Test
OSOM® Flu SARS-CoV-2 Combo Test
Magnetic Bead Separation Modules
MAG and HEATMAG
Anti-Cyclic Citrullinated Peptide Test
GPP-100 Anti-CCP Kit
New
Gold Member
Liquid Ready-To-Use Lp(a) Reagent
Lipoprotein (a) Reagent

Latest COVID-19 News

New Immunosensor Paves Way to Rapid POC Testing for COVID-19 and Emerging Infectious Diseases

Long COVID Etiologies Found in Acute Infection Blood Samples

Novel Device Detects COVID-19 Antibodies in Five Minutes



LGC Clinical Diagnostics