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Image: Immune T cells lymphocytes can seek and destroy a cell (green) infected with and making copies of SARS-CoV-2 (yellow) (Photo courtesy of US National Institute of Allergy and Infectious Diseases)

T Cells Recognize Recent SARS-CoV-2 Variants

Due to the proofreading ability of the coronavirus (CoV) RNA-dependent RNA polymerase, the evolution of the global SARS-CoV-2 viral population during the current pandemic has been relatively constrained as compared to other endemic RNA viruses that do not possess this ability. More...
15 Apr 2021
Image: Immune T cells lymphocytes can seek and destroy a cell (green) infected with and making copies of SARS-CoV-2 (yellow) (Photo courtesy of US National Institute of Allergy and Infectious Diseases)

T Cells Recognize Recent SARS-CoV-2 Variants

Due to the proofreading ability of the coronavirus (CoV) RNA-dependent RNA polymerase, the evolution of the global SARS-CoV-2 viral population during the current pandemic has been relatively constrained as compared to other endemic RNA viruses that do not possess this ability. More...
15 Apr 2021
BIOHIT  Healthcare OY
Image: Lower vitamin D levels are associated with metabolic syndrome and insulin resistance in systemic lupus (Photo courtesy of Nikki Yelton, RD)

Vitamin D Deficiency Linked to Metabolic Changes in Lupus Patients

Systemic lupus erythematosus (SLE), is the most common type of lupus. SLE is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage in the affected organs. It can affect the joints, skin, brain, lungs, kidneys, and blood vessels. More...
15 Apr 2021
Image: The Phadia 200 instrument is small enough to fit on a benchtop, and yet capable of running the complete menu of more than 700 different ImmunoCAP and EliA tests to aid in the diagnosis of allergy and autoimmune diseases (Photo courtesy of Thermo Fisher Scientific)

Circulating Calprotectin as Biomarker in Neutrophil-Related Inflammation

Calprotectin (CLP) acts as an endogenous ligand of different cell-surface proteins like Toll-like receptor 4 and receptor of advanced glycation end-products facilitating a local proinflammatory effect. CLP is mostly secreted through an active, calcium-dependent Protein Kinase C (PKC) pathway, next to the passive leakage from necrotic cells and release in neutrophil extracellular traps (NET). More...
15 Apr 2021
Image: The LUCIRA CHECK IT test kit (Photo courtesy of Lucira Health, Inc.)

First-Ever Single-Use, PCR Quality OTC COVID-19 At-Home Test Granted FDA EUA

The US Food and Drug Administration (FDA) has issued an Emergency Use Authorization (EUA) for the first-ever single use, over the counter (OTC) sale of a COVID-19 test kit that delivers PCR quality molecular accuracy in 30 minutes or less at home. More...
15 Apr 2021
Image: AnteoTech’s EuGeni Reader and in vitro rapid diagnostic test (Photo courtesy of AnteoTech Ltd.)

Nanoparticle Technology Based Digital Reader Supports High-Sensitivity, High-Specificity Rapid COVID-19 Testing

A new 15-minute COVID-19 antigen rapid test (ART) for a nanoparticle technology-based rapid test platform has received the Conformitè Europëenne (CE) Mark registration. More...
15 Apr 2021
Image: Inflammation of the pancreatic islets with mononuclear cells including T-cells is the hallmark of Type 1 diabetes (Photo courtesy A. van Halteren)

Type 1 Diabetes Onset Preceded by Gene Expression Changes

Type 1 diabetes (T1D) results from insufficient insulin production and is thought to result from an immune reaction against the body’s own pancreatic β cells. The exact cause of T1D remains unknown, although asymptomatic islet autoimmunity lasting from weeks to years before diagnosis raises the possibility of intervention before the onset of clinical disease. More...
14 Apr 2021