Study Reveals Varying Antibody Responses and Adverse Reactions Among Recipients of Different COVID-19 Vaccines
By LabMedica International staff writers Posted on 29 Sep 2021 |
A new study revealing how antibodies against the SARS-CoV-2 virus can vary among recipients of different COVID-19 vaccines was presented at the 2021 AACC Annual Scientific Meeting & Clinical Lab Expo.
The study by researchers at the Dartmouth-Hitchcock Medical Center (Lebanon, NH, USA) shows how antibody responses and adverse reactions can differ in recipients of the Moderna and Pfizer COVID-19 vaccines.
Vaccines have become essential tools in the fight against COVID-19, but it’s still unclear exactly how the antibodies generated from different vaccines change or wane over time. Meanwhile, the spread of the Delta variant and the rising number of breakthrough infections have both highlighted the importance of characterizing antibodies against SARS-CoV-2 in both vaccinated and unvaccinated individuals. Knowing more about antibody patterns could also help clinicians assess individuals’ immunity to SARS-CoV-2, in addition to helping with the diagnosis and management of patients.
In the new study, the researchers collected blood samples of 78 individuals who received the Moderna vaccine and 70 individuals who received the Pfizer vaccine, before the second vaccine dose, 14 days after the second dose, and 30 days after. The study participants also took a survey where they rated the severity of adverse effects and symptoms after vaccination. Overall, individuals who received the Moderna vaccine showed a higher antibody response against the viral spike protein compared with those who received the Pfizer vaccine (4,244 U/mL vs. 1,986 U/mL 30 days after dose two) and also reported stronger side effects. However, the researchers have cautioned that these differences could arise from confounding variables such as the higher mRNA dosage in the Moderna vaccine. The team also found that antibody responses had dropped 30 days after the second dose, regardless of the vaccine given.
“We can’t claim Moderna is better than Pfizer based on these results … but it does seem there is more of a response from Moderna at least in terms of the assay that we used,” said Michael Kelliher, PhD, of Dartmouth-Hitchcock Medical Center, who led the research. “How that correlates with the total adaptive immune response is unknown, and there’s still a decent amount of research that needs to be done on this topic.”
Related Links:
Dartmouth-Hitchcock Medical Center
Latest AACC 2021 News
- Study Showing Differing COVID-19 Antibody Profiles Among Vaccinated and Naturally Infected Individuals Presented at AACC 2021
- Novel Study on Performance of Coronavirus Tests in Children Presented at 2021 AACC Annual Scientific Meeting
- New Rapid Test That Identifies Deteriorating COVID-19 Patients with Greater Accuracy than Existing Tests Presented at AACC 2021
- New Blood Test for Occupational Stress Identifies Healthcare Professionals Burned out from COVID-19 Pandemic
- New Non-Invasive Saliva Test for Early and Accurate Detection of Prostate Cancer Presented at AACC 2021
- New Non-Invasive Blood Test for Colon Cancer Presented at 2021 AACC Annual Scientific Meeting
- Study Establishing Accurate Reference Intervals for Pregnant Patients Presented at AACC 2021
- New Test that Measures Antibodies in Girls Who Have Received HPV Vaccine Presented at AACC 2021
- Novel Insights on COVID-19 Vaccines and Virus Evolution, AI in the Clinic, and Miniaturization of Diagnostic Platforms Explored at AACC 2021
- Seegene Unveils New STARlet-AIOS All-in-One Solution for All Molecular Testing at AACC 2021
- Group K Diagnostics Demonstrates KromaHealth Kit that Enables Lab-Quality Results at Point-of-Care
- NGeneBio Showcases NGS-Based Oncology/Genetic Diseases Kits and NGenePlex nCoV qRT-PCR Kit Against COVID-19
- Visby Medical Presents New Portable PCR COVID-19 Test Kit at 2021 AACC Annual Scientific Meeting & Clinical Lab Expo
- Fluxergy Introduces First-of-Its-Kind Multi-Modal Laboratory Platform That Diagnoses COVID-19 On-Site in 60 Minutes
- Mammoth Biosciences Presents AACC 2021 Disruptive Technology Award Finalist CRISPR-Based Detection Platform
- Hologic Displays Automated Solutions And Expansive Diagnostic Menu to Help Labs Grow at AACC 2021