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Pathology

Image: Highly magnified view of brain tumor (glioma) cells (Photo courtesy of the University of California, San Francisco).

Panel of Genetic Biomarkers Separates Brain Tumors into Five Distinct Classes

A panel of three genetic biomarkers has been identified that can differentiate brain tumors into five principal groups.  More...
21 Jun 2015
Image: Histopathology of a biopsy smear from a patient with squamous cell carcinoma in the anal canal showing proliferation of atypical cells that infiltrate the stromal (Photo courtesy of Muñiz Hospital).

Biomarker Analysis Reveals Treatment Targets in Anal Cancer

Squamous cell anal carcinoma is a rare, human papillomavirus-associated malignancy accounting for 2% of digestive system cancers and usually these malignancies are detected early and successfully managed with chemoradiation.  More...
16 Jun 2015
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Computer-Aided Microscopy Facilitates Autoimmune Disease Diagnostics

A new software and immunofluorescence microscope system that supports automated imaging and interpretation for clinical diagnostics now provides specialized software for autoimmune disease identification, including analysis of anti-nuclear antibodies and anti-neutrophil cytoplasm antibodies.   More...
15 Jun 2015
Image: Immunohistochemical staining of human testis with antibody to AKAP4 shows location of the protein in spermatids (Photo courtesy of Novus Biologicals).

AKAP4 Identified as Accurate Biomarker for the Detection of Early Stage Lung Cancer

An initial survey identified the protein AKAP4 as a potential biomarker that could effectively distinguish between patients with and without non-small-cell lung cancer.  More...
14 Jun 2015
Image: The LightCycler 480 II rapid high-throughput, plate-based real-time polymerase chain reaction (PCR) amplification and detection instrument (Photo courtesy of Roche).

Ovarian Cancer-Specific Markers Leads to Early Diagnosis

While DNA carries all the instructions necessary for life, its actual sequence contains much more than just the genes that code for proteins, while in contrast messenger ribonucleic acids are complementary copies of just the genes.  More...
08 Jun 2015
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Programmable Probiotics Detect Cancer in Urine

Rapid advances in the forward engineering of genetic circuitry in living cells has positioned synthetic biology as a potential means to solve numerous biomedical problems, including disease diagnosis and therapy.   More...
07 Jun 2015
Image: The HiSeq 2000 sequencing system (Photo courtesy of the University of Queensland).

Blood Test Detects Breast Cancer Metastasis Early

Cell‐free circulating tumor DNA contains tumor‐specific chromosomal rearrangements that may be interrogated in blood plasma and used to detect metastatic breast cancer earlier.   More...
03 Jun 2015
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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