Technology

RPA-LF Assay Evaluated for Cutaneous Leishmaniasis in Colombia
Cutaneous leishmaniasis (CL) is a recognized public health challenge in the Americas, with an average of 55,000 cases per year between 2001 and 2018 in 17 countries of the region. Most cases (79.4%) have been acquired in and continue to occur in rural areas. More...17 May 2021

Rapid, Direct-to-Digital Prostate Biopsy Pathology Evaluated
Increasing adoption of digital pathology promises marked improvements in reproducibility, efficiency, and accuracy of tissue-based diagnostics by facilitating routine remote expert consultation and enabling computerized image analysis for clinical use. More...13 May 2021

Gel and Capillary Electrophoresis Compared for Human Proteins
The electrophoresis of serum proteins remains a laboratory cornerstone for the diagnosis and monitoring of patients with plasma cell disorders, such as monoclonal gammopathy of undetermined significance, multiple myeloma, Waldenström macroglobulinemia, and AL amyloidosis. More...12 May 2021

Developed Immunoassay Predicts Benefits of Anti-PD-1 Therapy in NSCLC
Lung cancer is the most common cause of cancer-related deaths worldwide. However, current targeted therapies and immunotherapies have gradually improved patient survival. Anti-programmed cell death-1 (PD-1) antibodies (Abs) are key drugs in non-small-cell lung cancer treatment; however, clinical benefits with anti-PD-1 monotherapy are limited. More...12 May 2021

Holographic Histopathology Enables Fast, Precise Diagnostics
Microscopic assessment of biopsied and resected tissues is central to understanding the underlying pathophysiology and clinical states of many patients. Because most microscopic specimens are translucent to visible light, conventional histological methods achieve image contrast using exogenous labels. More...10 May 2021

A Novel Capsule-Based Smell Test for Diagnosis of Neurological and Respiratory Diseases
To aid in diagnosing diseases where loss of the sense of smell is a symptom, such as in chronic neurological conditions like Parkinson's and Alzheimer's diseases and in acute respiratory infections such as that caused by COVID-19, a team of researchers at Queen Mary University of London (United Kingdom) developed a novel smell testing kit based on capsules of aromatic oils placed between two strips of single-sided tape. More...10 May 2021

Spatial Tissue Profiled by Imaging-Free Molecular Tomography
Spatially resolved molecular atlases help scientists understand where different types of cells are located in the body and map their gene expression in specific locations in tissues and organs. However, many sequencing modalities lack spatial counterparts. More...06 May 2021
In Other News
Different Methods Compared for Isolating Fungal DNA
Breath Test Determines Severity of Methylmalonic Acidemia Disease
Breast Cancer Histopathology Employs Infrared Spectroscopic Imaging
Immunoassay Developed for Quantitative Detection of Serum Interleukinâ6
NMR-Based Method Measures Circulating Blood Citrate Levels
PCR Method Identifies Microsatellite Instability in Tumor-Derived Samples
Epidermal Patch Simultaneously Monitors Hemodynamic and Metabolic Biomarkers
Hemoglobin Levels Measured with AI Microscope, Microfluidic Chips
Magneto-Optical Diagnosis Evaluated for Symptomatic Malaria
Pulse-Controlled Amplification Tested for Infectious Disease Diagnostics
Biosensing Microneedle Patch Quantifies Biomarkers in Interstitial Fluid
Automated Urine Microscopy Analyzer Detects Uropathogen Morphology
MALDI-TOF-MS Evaluated for Rapid Diagnosis of Bacteremia and Fungemia
Novel Biomarker Candidate for Amyotrophic Lateral Sclerosis Explored
Quick Ultra-Sensitive System Identifies Multidrug-Resistant Bacteria
Lab-on-a-Chip Infection Test Provides Cheaper, Faster Portable Diagnostics
Interstitial Fluid Sampled from Skin Using a Microneedle Patch
Nanodiamonds Dramatically Boost Immunoassay Sensitivity
Fast Antibacterial Susceptibility Testing by Measuring Electron Transfer Metabolism
Breath Ammonia Biomarker Predicts Kidney Function in CKD Patients
Paper Diagnostic Directly Measures Fibrinogen in Whole Blood
Fecal Immunochemical Test Assessed in Suspected Colorectal Cancer
Artificial Enzyme Increases Sensitivity of Alzheimer's Disease Immunoassay
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