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Technology

Image: Dr. Brian Geiss displays a gold microwire that is one-fourth the size of a human hair (Photo courtesy of John Eisele, Colorado State University Photography).

New Test May Replace ELISA for Detecting Antibodies

A microwire-based test may replace enzyme-linked immunosorbent assay (ELISA) as the primary method to detect antibodies specific for pathogenic microorganisms in patient's sera. More...
15 Apr 2019
Image: The diagram shows how sPLA2-IIA binding to anionic phospholipids leads to its activation and promotes inflammation. The oxidation of the phospholipids produces stress, which causes the anionic phospholipids phosphatidylserine (PS) and phosphatidylethanolamine (PE) to be transported to the outer leaflet. This reaction activates cationic sPLA2-IIA. The higher activity of sPLA2-IIA promotes the hydrolysis of the outer leaflet phospholipids into arachidonic acid and lysophospholipids. Through the cyclooxygenase and 5-lipoxygenase enzymes, arachidonic acid is converted into prostaglandins, leukotrienes, and other inflammatory eicosanoids (Photo courtesy of Randox).

New Automated Assay Measures Levels of sPLA2-IIA

Phospholipase A2 (PLA2s) are a family of enzymes that cleave the fatty acid in position two of phospholipids, hydrolyzing the bond between the second fatty acid “tail” and the glycerol molecule. More...
08 Apr 2019
Image: The 5977B High Efficiency Source (HES) GC/MSD System (Photo courtesy of Agilent Technologies).

Signature Odor of Parkinson's Disease Discovered

Parkinson's disease is a neurodegenerative disorder that leads to progressive brain cell death and extensive loss of motor function. Despite many investigations being conducted on this disease, there are no definitive diagnostic tests currently available. More...
02 Apr 2019
Image: A close-up of the CRISPR-Chip device (Photo courtesy of Keck Graduate Institute).

Biosensor Device Uses CRISPR-Cas9 to Detect Target DNA Sequence

A team of biomedical engineers has developed and tested a graphene-based biosensor device that uses CRISPR/Cas9 technology to enable the digital detection of a target DNA sequence within intact genomic material. More...
01 Apr 2019
Image: The CR Dot (CRD) Paper Test: each kit had two label papers incorporated, and a visual colorimetric scale marked as strongly positive (SP), weak positive (WP) and negative (NEG). The kit contained a syringe prefilled with Congo Red dye (Photo courtesy of The Ohio State University Wexner Medical Center).

Urine Test Allows for Rapid Preeclampsia Diagnosis

Hypertensive disorders affect 15% of pregnancies and account for one quarter of the antenatal admissions. Preeclampsia (PE) is a multisystem disorder specific to human pregnancy, and its incidence varies from 5% to 60% of gestations, depending on maternal co-morbidities. More...
27 Mar 2019
Image: A paper-based microfluidic device enables multiplex LAMP-based detection of malaria in blood (Photo courtesy of University of Glasgow).

Paper-Based Technology Enables Malaria Detection

Populations living in remote rural communities would benefit from rapid, highly sensitive molecular, DNA-based diagnostics to inform the correct and timely treatment of infectious diseases. More...
21 Mar 2019
Image: The BinaxNOW Influenza A & B Card 2 and Digival reader (Photo courtesy of Abbott).

Reformulated Influenza Rapid Test Made Available

Influenza is a viral infection of the upper respiratory system, which includes the nose, bronchial tubes, and lungs. Influenza can make people of any age ill. Although most people, including children, are ill with influenza for less than a week, some have a much more serious illness and may need to be hospitalized. Influenza may also lead to pneumonia or death. More...
19 Mar 2019
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