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Image: Normal and abnormal control cells from the ClearLLab 10C kit (Photo courtesy of Beckman Coulter).

Flow Cytometry Leukemia/Lymphoma Antibody Panel Receives Approval

A panel of immune-phenotyping flow cytometer reagents that identifies both lymphoid and myeloid cell lines has been granted diagnostic marketing clearance by the [U.S.] Food and Drug Administration to complement its European IVD classification. More...
06 May 2019
Image: The VERSAmax microplate reader (Photo courtesy of Molecular Devices).

Novel Software Reduces Variability in ELISA Biomarker Tests

Protein biomarkers are measured frequently in plasma, serum or other matrices by solid phase Enzyme-Linked Immunosorbent Assay (ELISA) methods in which the antigen of interest in the sample is bound by antibodies and the amount of bound antigen is proportional to the signal strength that develops in the assay. More...
30 Apr 2019
Image: The Early Sepsis Indicator kit was designed for use on automated hematology instruments such as the DxH 900 analyzer (Photo courtesy of Beckman Coulter).

Early Sepsis Detection Test Approved for U.S. Marketing

A test for the early detection of sepsis has been approved for marketing in the United States as an in vitro diagnostic product. More...
29 Apr 2019
Image: The MinION, a small hand-held device that \"decodes\" individual strands of DNA in real-time (Photo courtesy of Dr. Sophie Zaaijer).

DNA Sequencing Reduces Huntington's Disease Diagnosis

Huntington's disease is an inherited neuro-degenerative disorder, which stops parts of the brain working properly, with symptoms worsening over time, and is usually fatal within 20 years. Currently individuals with symptoms of Huntington's disease have a blood test and can wait up to four weeks for the result. More...
23 Apr 2019
Image: The Minicare I-20 handheld diagnostics platform is designed to detect multiple target molecules at very low concentrations in a single ‘finger-prick’ blood sample, and display the results on a handheld analyzer within minutes (Photo courtesy of Philips Healthcare).

B-Type Natriuretic Peptide Sandwich Immunoassay Evaluated

The measurement of circulating natriuretic peptides (NP) is considered to be a useful marker of myocardial function, and international guidelines recommend its use for the diagnosis of patients with heart failure (HF), and in particular ruling out the presence of HF. More...
23 Apr 2019
Image: Dr. Brian Geiss displays a gold microwire that is one-fourth the size of a human hair (Photo courtesy of John Eisele, Colorado State University Photography).

New Test May Replace ELISA for Detecting Antibodies

A microwire-based test may replace enzyme-linked immunosorbent assay (ELISA) as the primary method to detect antibodies specific for pathogenic microorganisms in patient's sera. More...
15 Apr 2019
Image: The diagram shows how sPLA2-IIA binding to anionic phospholipids leads to its activation and promotes inflammation. The oxidation of the phospholipids produces stress, which causes the anionic phospholipids phosphatidylserine (PS) and phosphatidylethanolamine (PE) to be transported to the outer leaflet. This reaction activates cationic sPLA2-IIA. The higher activity of sPLA2-IIA promotes the hydrolysis of the outer leaflet phospholipids into arachidonic acid and lysophospholipids. Through the cyclooxygenase and 5-lipoxygenase enzymes, arachidonic acid is converted into prostaglandins, leukotrienes, and other inflammatory eicosanoids (Photo courtesy of Randox).

New Automated Assay Measures Levels of sPLA2-IIA

Phospholipase A2 (PLA2s) are a family of enzymes that cleave the fatty acid in position two of phospholipids, hydrolyzing the bond between the second fatty acid “tail” and the glycerol molecule. More...
08 Apr 2019
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