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Image: The transverse section of a chorionic villus (Photo courtesy of Wikimedia Commons).

Method Developed for Enriching Trophoblast Population in Samples

A recent paper described a technique to increase the proportion of placental trophoblast cells in cervical samples by 700%, which enables individual trophoblasts to be picked out for genetic testing. More...
02 Sep 2019
Image: A diagram illustrating the combined use of bioorthogonal ligation (i.e., the reaction between Tz and TCO) and disulfide cleavage–driven by DTT to enable capture and release of CTCs using Click Chips (Photo courtesy of University of California, Los Angeles).

CTC Purification Enables Identification of Cancer-Linked Genetic Arrangements

The use of circulating tumor cells (CTCs) as a surrogate tumor source for molecular profiling of disease offers a potential noninvasive diagnostic solution for understanding underlying tumor biology, guiding treatment interventions, and monitoring disease progression. More...
29 Aug 2019
Image: The 3320 osmometer used to assess urine osmolality, a measure of urine concentration and hydration (Photo courtesy of Advanced Instruments).

Urinary Hydration Markers Tested for Storage Condition Validity

Fluid balance is an aspect of the homeostasis of organisms in which the amount of water in the organism needs to be controlled, via osmoregulation and behavior, such that the concentrations of electrolytes in the various body fluids are kept within healthy ranges. More...
27 Aug 2019
Image: Researchers used metallic ink to screen-print an antenna and sensor onto a stretchable sticker designed to adhere to skin and track pulse and other health indicators, and transmit these readings to a receiver on a person\'s clothing (Photo courtesy of Bao Lab, Stanford University).

Study Supports Body Area Sensory Networks for Diagnostic Monitoring

The first steps have been taken on the path leading to development of a body area sensor network, which is a collection of networked sensors that can be used to remotely monitor human physiological signals. More...
26 Aug 2019
Image: A circulating tumor cell (arrow) diagnosed by the isolation by size of epithelial tumor cells (ISET) test (The pores of the filter are also visible) (Photo courtesy of Chichiselector).

Circulating Tumor Cells Directly Detected in Blood Samples

Tumor cells circulating in blood are markers for the early detection and prognosis of cancer. However, detection of these cells is challenging because of their scarcity. More...
21 Aug 2019
Image: Scientists combined multiphoton microscopy with automated image and statistical analysis algorithms to distinguish between healthy and diseased tissue. In this image, collected in a completely label-free, noninvasive manner, collagen is colored green while ovarian metastatic cell clusters are presented in red (Photo courtesy of Tufts University).

Non-Invasive Imaging Detects Cancer at Molecular Level

For cancer patients the presence of metastases dictates the staging assessment, which in turn defines the appropriate treatment path selected. For gynecological malignancies, like ovarian carcinoma, it is of immense importance to differentiate between localized and metastatic disease status as that drastically affects management. More...
20 Aug 2019
Image: An MIT-invented microfluidics device could help doctors diagnose sepsis, a leading cause of death in US hospitals, by automatically detecting elevated levels of a sepsis biomarker in about 25 minutes, using less than a fingerprick of blood (Photo courtesy of Felice Frankel).

Microfluidic Device Rapidly Diagnoses Sepsis

Sepsis is a life-threatening condition and early diagnosis is crucial to ensure that treatment is not delayed. However, as current diagnostic methods are imprecise, the condition is misdiagnosed in 30% of patients. More...
15 Aug 2019
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