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Immunology

Image: The LUNA-FL Dual Fluorescence Cell Counter (Photo courtesy of Logos Biosystems)

Tumor Suppressor Adenomatous Polyposis Coli Regulates T Lymphocyte Migration

Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disease that often results from germline mutations in the adenomatous polyposis coli (APC) gene, a tumor suppressor and polarity regulator. APC protein regulates the Wnt/β-catenin signaling pathway as a component of the β-catenin destruction complex. More...
20 Apr 2022
Image: Testing Neurofilament Light (NF-L) chain in blood samples to monitor neurodegenerative diseases: qualification of an ultrasensitive immuno-assay using clinical serum and plasma samples (Photo courtesy of Advanced BioScience Laboratories, Inc)

Neurofilament Light Biomarker Linked With Parkinson's Disease

Parkinson's disease is caused by a loss of nerve cells in part of the brain called the substantia nigra. This leads to a reduction in a chemical called dopamine in the brain. Blood biomarkers may allow earlier identification of Parkinson’s disease (PD), Parkinsonism, and poor PD-related outcomes, such as physical functioning. More...
19 Apr 2022
Image: Photo micrograph of Yersinia pestis bacteria stained with direct, fluorescent, antibody (Photo courtesy of Pixnio)

Lateral Flow Immunoassay Developed for Detecting Yersinia Pestis

Yersinia pestis is the causative agent of plague, a zoonosis associated with small mammals. Plague is a severe disease, especially in the pneumonic and septicemic forms, where fatality rates approach 100% if left untreated. More...
07 Apr 2022
Image: Histopathology of pediatric non-alcoholic fatty liver disease (NAFLD This trichrome stain illustrates zone 1 steatosis, portal fibrosis, and a ductular reaction, which characterize pediatric NAFLD (Photo courtesy of Elizabeth M. Brunt MD)

Serum Antinuclear Antibody Correlated in Hispanic Pediatric Patients With NFLD

Non-alcoholic fatty liver disease (NAFLD), also known as metabolic (dysfunction) associated fatty liver disease (MAFLD), is excessive fat build-up in the liver without another clear cause such as alcohol use. Obesity and type 2 diabetes are strong risk factors for NAFLD. More...
06 Apr 2022
Image: Livedo Reticularis: this is one of the most important physical signs in Antiphospholipid syndrome (APS) and is felt by many physicians to be an additional risk factor for the risk of APS clinical events, over and above the presence of antiphospholipid antibody (Photo courtesy of Graham Hughes and Shirish Sangle)

Pediatric Antiphospholipid Syndrome Diagnosis Methods Reassessed

Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by thrombotic events and/or pregnancy morbidity in the setting of persistently positive antiphospholipid antibodies (aPL). More...
30 Mar 2022
Image: Photomicrograph of a blood sample specimen, revealed the presence of two flagellated, Trypanosoma cruzi parasites (Photo courtesy of Dr. Mae Melvin/CDC)

Double-Antigen Sandwich ELISA Detects Antibodies to Trypanosoma cruzi

Chagas disease (CD), also known as American trypanosomiasis, is a potentially life-threatening vector-borne tropical zoonosis caused by the protozoan parasite Trypanosoma cruzi. The estimated prevalence of CD in 21 Latin American countries where it is considered endemic exceeds five million individuals; CD accounts for approximately 7,500 deaths annually. More...
29 Mar 2022
Image: Photomicrograph of classic Hodgkin lymphoma (cHL) fine needle aspiration from a lymph node. The micrograph shows a mixture of cells common in cHL: eosinophils, Reed-Sternberg cells, plasma cells, and histocytes (Photo courtesy of Nephron)

Flow Cytometric Immunophenotyping Assessed for Classic Hodgkin Lymphoma

The diagnosis of classic Hodgkin lymphoma (CHL) requires morphologic and immunophenotypic identification of neoplastic Hodgkin and Reed-Sternberg cells (collectively referred to as HRS cells) intermixed with a background of reactive lymphocytes, histiocytes, plasma cells, and eosinophils. More...
24 Mar 2022
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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