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Immunology

Image: Multiphase polymer systems confine unique antibody-conjugated beads that bind with high sensitivity and specificity to plasma protein biomarkers, eliciting amplified luminescent signals. The signal intensity from the beads is proportional to the levels of disease biomarkers in the blood plasma (Photo courtesy of World Scientific).

Aqueous Two-Phase Systems Enable Homogeneous Immunoassay Multiplexing

A novel test simplifies disease detection by enabling simultaneous detection of multiple proteins in blood plasma in only two hours.  More...
28 Jul 2014
Image: Enzyme-linked immunosorbent kit (ELISA) specific for human copeptin (Photo courtesy of USCN Life Science).

Preeclampsia Biomarker Detected Very Early In Pregnancy

A biomarker has been discovered that could give expecting mothers and their doctors the first simple blood test to reliably predict that a pregnant woman may develop preeclampsia, at least as early as six weeks into the pregnancy. More...
24 Jul 2014
Image: Taenia solium cysticerci, which represent the larval or intermediate, immature developmental stages of this pork tapeworm (Photo courtesy of Dr. George R. Healy).

Screening Tool Simplifies Serological Diagnosis of Neurocysticercosis

The availability of a rapid serological diagnosis that targets stage-specific antibodies for human cysticercosis is considered very helpful in control programs for estimating the sero-prevalence or burden of the disease in susceptible population groups. More...
24 Jul 2014
Image: The inexpensive type-1 diabetes microchip test relies on fluorescence-based antibody detection. The innovation is that the glass plates forming the base of each microchip are coated with an array of nanoparticle-sized islands of gold, which intensify the fluorescent signal, enabling reliable antibody detection (Photo courtesy of Prof. Brian Feldman, Stanford University, and Nature Medicine).

Microchip Invented for Faster, Simpler Type-1 Diabetes Diagnosis, Risk Assessment, and Biomarker Discovery

Researchers have succeeded in developing a low-cost, portable, nanotech microchip-based test for diagnosing type-1 diabetes that would speed diagnosis and screening, and enable new approaches to studying how the disease develops. More...
23 Jul 2014
Image: Schematic representation of signaling pathways involved in lipopolysaccharide (LPS) induced tumor necrosis factor-alpha (TNFα) production in human cells (Photo courtesy of Dr. Laurence Hoareau).

Immune Function Predicts Infection for Pediatric Trauma Patients

An immune marker that predicts which patients are likely to develop a hospital-acquired infection has been identified in critically ill children with traumatic injuries. More...
23 Jul 2014
Image: Histology of lung tissue from a chronic beryllium disease patient showing granulomatous tissue (Photo courtesy of the Cleveland Clinic).

Beryllium Causes Deadly Lung Disease

How the metal beryllium triggers a deadly immune response in the lungs has been discovered using detailed maps of molecular shapes and the electrical charges surrounding them.   More...
16 Jul 2014
Image: Histology of a brain from a patient with cerebral malaria showing sequestration of parasites, pigmentation and obstruction of blood vessels (Photo courtesy of Chulalongkorn University).

Cerebral Malaria Biomarker Quantified

The detection, semi-quantification, and clinical use of the Plasmodium falciparum histidine-rich protein-2 as a parasite antigen biomarker for cerebral malaria had been investigated.  More...
16 Jul 2014
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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