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Immunology

Image: The geographic distribution of Japanese encephalitis (in red) (Photo courtesy of the CDC – US Centers for Disease Control and Prevention).

Dried Cerebrospinal Fluid Spots Detect Anti-Japanese Encephalitis IgM

The use of filter paper as a simple, inexpensive tool for storage and transportation of blood, “Dried Blood Spots” or Guthrie cards, for diagnostic assays is well-established, but in contrast, there are a paucity of diagnostic evaluations of dried cerebrospinal fluid spots.  More...
29 Mar 2016
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Immune Cells Adapt Inefficiently in Patients with Uncontrolled HIV

Antibodies derived from a type of immune cell found in unusually high numbers in human immunodeficiency virus-infected individuals with chronically uncontrolled virus levels are less effective at neutralizing HIV than antibodies derived from a different type of immune cell more common in people without HIV.  More...
28 Mar 2016
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Immunoassay Systems Evaluated for Detection of Antiphospholipid Antibodies

Antiphospholipid syndrome or antiphospholipid antibody syndrome, or also Hughes syndrome, is an autoimmune, hypercoagulable state caused by antiphospholipid antibodies.  More...
28 Mar 2016
Image: The Videssa Breast diagnostic test provides accurate early detection and typing of breast cancers by combining anatomical evidence from imaging with evidence from its proteomics test for proteins released into the blood system by cancer tumors (Image courtesy of Provista Diagnostics).

Age Should Be Considered in Developing Diagnostic Assays

In a new study on breast cancer, blood test results have demonstrated age-related differences in Tumor-Associated Antibodies, showing for the first time age-related differences that should be taken into consideration when developing diagnostic tests.  More...
23 Mar 2016
Image: Illustration of a protocol showing a pathway to develop core-shell nanoparticle/hybrid graphene oxide based multi-functional platform label-free SERS detection of β-amyloid toward developing a portable point-of-care blood test to monitor Alzheimer’s disease progression (Figure courtesy of Teresa Demeritt et al., 2015, ACS Appl. Mater. Interfaces; Copyright ACS-2015).

Developing POC Tests for Alzheimer’s to Improve Monitoring and Management of the Disease

Toward development of a portable point-of-care biosensor for Alzheimer’s disease, a new review explores recent advancements in nano-enabling electrochemical beta-amyloid-sensing technologies.  More...
22 Mar 2016
Image: The ScheBo Tumor M2-PK Stool sandwich enzyme-linked immunosorbent assay (Photo courtesy of ScheBo Biotech AG).

Enzyme Signpost Points to Better Bowel Cancer Test

A sensitive screening tool for colorectal cancer that detects a special isoenzyme of pyruvate kinase, termed M2-PK, which leaks from the cancerous tissue into the bowel, can then be found in feces.   More...
20 Mar 2016
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Diagnostic Accuracy of Immunochromatographic Fecal Calprotectin Assay Evaluated

Fecal calprotectin is a noninvasive marker for bowel diseases and it is of high value for following disease activity in Crohn's disease and ulcerative colitis.  More...
20 Mar 2016
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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