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Immunology

Image: ABO grouping for A, B, AB, and O as indicated by the presence of teal color in the observation zone (red dashed box). Images of multiplexed assays testing (C) ABO/Rh and (D) rare blood systems (Photo courtesy of Third Military Medical University).

POC Assay Developed for Reliable Blood Grouping

Rapid and accurate blood grouping plays a critical role in multiple scientific disciplines, particularly in the biological and medical sciences and especially for pregnancy, blood transfusion, and bone marrow transplantation. More...
07 Apr 2017
Image: Trypanosoma cruzi trypomastigote in a thin blood smear stained with Giemsa from a patient with Chagas disease (Photo courtesy of the CDC).

Performance of Chagas Disease Genotyping Assay Evaluated

Chagas disease remains a significant public health issue infecting six to seven million people worldwide. The factors influencing the clinical heterogeneity of Chagas disease have not been elucidated, although it has been suggested that different clinical outcome may be associated with the genetic diversity of Trypanosoma cruzi isolates. More...
07 Apr 2017
Image: The NanoSight NS300 instrument provides an easy-to-use, reproducible platform for nanoparticle characterization (Photo courtesy of Malvern Instruments).

Test Discovered for Earlier Detection of Transplant Rejection

A method has been discovered that appears to provide earlier warning of organ transplant rejection compared to standard methods, and requires only a blood test rather than a more invasive and painful needle biopsy. More...
06 Apr 2017

Simple Urine Test Helps Track ALS Progression

The continued failure of amyotrophic lateral sclerosis (ALS) clinical trials and the absence of therapeutic options for this fatal disease have fueled interest in the prospect that biomarkers may hold great promise for advancing therapy development efforts. More...
05 Apr 2017
Image: The diagnosis, understanding, & treatment of Crohn’s disease may have now received a helping hand from a study aimed at developing a better blood test for the disease (Photo courtesy of the Biodesign Institute, Arizona State University).

Immunoproteomics Identifies New Biomarkers for Crohn’s Disease

Using a new screening approach, a study aimed at developing a better blood test for Crohn’s disease (CD) successfully identified several antibodies that could serve as diagnostic markers. More...
23 Mar 2017
Image: The pituitary-specific transcription factor PIT-1 plays an essential role in producing growth hormone (GH), thyroid stimulation hormone (TSH), and prolactin (PRL). Researchers have discovered that a thymoma was detected in examined cases of “anti-PIT-1 antibody syndrome”. PIT-1 expression was abnormally increased within the thymoma and this likely evoked the immune tolerance breakdown and hypopituitarism that occurs in patients with this autoimmune disorder (Photo courtesy of Kobe University).

Autoimmune Disease Trigger Associated with Thymoma Tumors

Researchers have discovered that a newly-identified autoimmune endocrine disease – “Anti-PIT-1 antibody syndrome” – that leads to hypopituitarism is likely caused by overexpression of PIT-1 in the thymoma type of tumor originating from the thymic gland. More...
16 Mar 2017
Image: A diagram of the DiviTum assay: BrdUTP is incorporated into a solid-phase DNA-strand. Incorporated BrdU is detected using an anti-BrdU monoclonal antibody conjugated to the signal generating enzyme alkaline phosphatase. The level of BrdU incorporated over time is proportional to the level of thymidine kinas activity in the sample (Photo courtesy of Biovica).

Biomarker Assay Evaluates Efficacy of Novel Breast Cancer Drug

Breast cancer is the most common form of cancer among women today, affecting approximately 362,000 individuals in the European Union (EU) and 233,000 in the USA each year. Around 1,600 new cases are diagnosed every day and 136,000 deaths occur annually (EU+USA). More...
03 Mar 2017
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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