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Molecular Diagnostics

Image: A micrograph of prostatic adenocarcinoma (conventional, acinar type) with perineural invasion. Prostate biopsy, H&E stain (Photo courtesy of Wikimedia).

Gene Mutations Associated with Aggressive Prostate Cancer

An international study has identified inherited genomic DNA mutations in the Kallikrein 6 (KLK6) gene region that are connected to a predisposition for some men to develop aggressive prostate cancer (PC). More...
28 Mar 2017
Image: New research shows the gene Cadherin 2 can lead to sudden death among young people and athletes with genetically inherited ARVC (Photo courtesy of Flipboard).

Gene Discovered Can Cause Sudden Cardiac Death

Researchers have found that mutations in the gene Cadherin 2 (CDH2) can lead to sudden death among young people and athletes with genetically inherited arrhythmogenic right ventricular cardiomyopathy (ARVC), which predisposes patients to cardiac arrest and is a major cause of unexpected death in seemingly healthy young people. More...
22 Mar 2017
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Image: The structure of the CDH2 (cadherin 2) protein (Photo courtesy of Wikimedia Commons).

Genome Researchers Identify Mutation Linked to Cardiac Disorder

An international team of genome researchers has identified a gene variant linked to the potentially lethal cardiac disorder ARVC (Arrhythmogenic right ventricular cardiomyopathy). More...
22 Mar 2017
Image: The structure of the SEMA4D protein (Photo courtesy of Wikimedia Commons).

Mutation Linked to Obesity Identified in Genome Study

Results obtained during what was probably the first genome-wide association study (GWAS) for body mass index (BMI) to be conducted in continental Africa identified a gene, carried by about 1% of West Africans, linked to hereditary obesity. More...
21 Mar 2017
Image: Researchers say those who have a genetic disposition for storing fat deposits primarily at their waistline are at a higher risk of developing diabetes and coronary heart disease (Photo courtesy of Massachusetts General Hospital).

Body Type Can Increase Risk of Heart Disease and Diabetes

Researchers have identified a pattern of gene variants associated with an “apple-shaped” body type, in which weight is deposited around the abdomen rather than in the hips and thighs, increases risk for type 2 diabetes and coronary heart disease, as well as the incidence of several cardiovascular risk factors. More...
17 Mar 2017
Image: A scanning electron micrograph (SEM) of ovarian cancer cells (Photo courtesy of Steve Gschmeissner / SPL).

High Levels of Biomarker Protein Indicate Poor Prognosis for Cancer Patients

The surface biomarker protein CD151 has been linked to a poor prognosis for patients suffering from high-grade serous ovarian cancer (HGSC), the most common and lethal subtype of the disease. More...
15 Mar 2017

Test Markers Identify Cancer DNA and Pinpoint Tumor Location

A team of molecular geneticists has developed a diagnostic tool that identifies circulating cancer DNA and determines the organ in which the tumor is located. More...
15 Mar 2017
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