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Molecular Diagnostics

Image: Since fluid from the Pap test occasionally contains cells from the endometrium or ovaries, scientists found they could detect cancer cells from these organs that are present in the fluid by using different brushes (Photo courtesy of Johns Hopkins University).

Cervical Fluid Test Developed for Gynecological Cancers

Together, endometrial and ovarian cancers account for about 25,000 deaths each year and are the third leading cause of cancer-related mortality in women in the USA. Most of these deaths are caused by high-grade tumor subtypes, which tend to metastasize before the onset of symptoms. More...
03 Apr 2018
Image: In an outbreak of Legionnaires\' disease, finding the exact source as quickly as possible is essential to preventing further infections. Investigators have now developed a rapid test that identifies Legionella pneumophila in less than one hour. The photograph shows the use of the LegioTyper-chip with the MCR microarray analysis platform (Photo courtesy of Jonas Bemetz, Technical University of Munich).

Rapid Detection of Legionella Offered for Commercial Water Systems

A rapid (approximately one hour) DNA microarray-based assay is set to replace classical culture methods for identification of Legionella bacteria in commercial water systems. More...
02 Apr 2018
Image: The friction ridges on a finger (Photo courtesy of Wikimedia Commons).

New Fingerprint Assay Accurately Identifies Users of Heroin and Cocaine

A test protocol based on liquid chromatography-mass spectrometry (LC-MS) analysis accurately detects levels of illegal drugs in a single fingerprint from drug users while eliminating those who had only passive contact with a drug user. More...
02 Apr 2018
Image: The HiSeq2000 instrument used for whole-genome sequencing targeted resequencing, gene expression level detection, DNA methylation profiling, de novo sequencing, metagenomic studies, and ChiP-seq (Photo courtesy of Illumina).

Chromosome Interaction Profiling Reveals Cancer Risk Genes

Breast cancer is a heterogeneous disease with two main subtypes defined by the presence (ER+) or absence (ER−) of the estrogen receptor. Approximately 80% of newly diagnosed breast cancers are ER+ although this proportion varies with age at diagnosis and ethnicity. More...
29 Mar 2018
Image: The Applied Biosystems Step One Real-Time PCR (Photo courtesy of Thermo Fisher Scientific).

Circulating Blood Markers Identified for Abnormal Heart Rhythms

The irregular heart rhythm atrial fibrillation (AF) increases the risk of stroke and heart failure, but is often undiagnosed because of a lack of symptoms. AF increases the risk of developing strokes, heart failure, and even dementia. More...
29 Mar 2018
Image: The 5500xl SOLiD genetic analyzer (Photo courtesy of Life Technologies).

Synesthesia Family Exomes Lead to Rare Gene Variants

Synesthesia is a neurological phenomenon that causes unusual links between sensory experiences, and its molecular basis is completely unknown. Synesthesia is a perceptual phenomenon in which stimulation of one sensory or cognitive pathway leads to automatic, involuntary experiences in a second sensory or cognitive pathway. More...
22 Mar 2018
Image: The NextSeq 500 benchtop sequencer delivers on-demand exome, transcriptome and whole-genome sequencing (Photo courtesy of Illumina).

Distinct Epigenetic Features Found in Alzheimer's Brains

Aging is the strongest risk factor for Alzheimer’s disease (AD), although the underlying mechanisms remain unclear though AD tends to coincide with certain chromatin shifts in the aging brain. More...
21 Mar 2018
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.