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Molecular Diagnostics

Image: The synaptic sheddome: protein ectodomains shed into the cerebrospinal fluid (Photo courtesy of Dr. Peter Penzes, Northwestern University)

Certain Protein Ectodomains in Cerebrospinal Fluid Are Diagnostic Biomarkers for Autism

Abnormally low levels of a protein biomarker, which can be detected in the cerebrospinal fluid (CSF), have the potential to be the basis for diagnosis of autism and related neurological disorders. More...
27 Dec 2021
Image: The EZ1 Advanced XL performs automated nucleic acid purification for a wide range of sample types relevant for molecular diagnostics, human identity testing, and gene expression analysis (Photo courtesy of Qiagen).

Bacterial Communities Diverge in The Lower Airways of CF Children

Chronic airway infection and inflammation resulting in progressive, obstructive lung disease is the leading cause of morbidity and mortality in people with cystic fibrosis (CF). Culture-independent, molecular approaches have broadened the view from a few individual pathogens to more complex and dynamic polymicrobial communities. More...
23 Dec 2021
Image: Histopathology of a typical neuroblastoma with rosette formation (Photo courtesy of Dr. Mark Applebaum, MD)

Intratumor Heterogeneity Analyzed in Neuroblastoma

Neuroblastoma is the most common solid pediatric tumour, accounting for 15% of cancer-related deaths in early childhood and especially for patients directly diagnosed with high-risk neuroblastoma have a poor prognosis. More...
22 Dec 2021
Image: How epigenetic mechanisms can affect health (Photo courtesy of [U.S.] National Institutes of Health)

Epigenetic Biomarkers for Early Rheumatoid Arthritis Detection

DNA methylation alterations, termed epimutations, have demonstrated the potential to be used as a biomarkers for rheumatoid arthritis to improve the detection and clinical management of the disease. More...
20 Dec 2021
Image: The NovaSeq 6000 offers deeper and broader coverage through advanced applications for a comprehensive view of the genome and unlocks the full spectrum of genetic variation and biological function with high-throughput sequencing (Photo courtesy of Illumina)

Genomic Screening Can Identify Risk for Amyloid Cardiomyopathy

Transthyretin amyloidosis (ATTR) a is a rare, progressive disease characterized by the abnormal buildup of amyloid deposits composed of misfolded transthyretin protein in the body’s organs and tissues. ATTR can be hereditary and lead to a spectrum of other diseases and conditions, including cardiomyopathy, a common precursor to heart failure. More...
15 Dec 2021
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Cheek Swab Test Could Identify Biomarkers for Rheumatoid Arthritis

Cells from a cheek swab revealed biomarkers for rheumatoid arthritis that could lead to a way to diagnose and begin treatment before the disease develops, according to a new study. More...
14 Dec 2021
Image: Electron micrograph of human papilloma virus (HPV) (Photo courtesy of [U.S.] National Institutes of Health via Wikimedia Commons)

Rapid Biopsy Approach Shortens Time Required to Diagnose HPV-linked Head and Neck Cancers

A non-invasive, liquid biopsy approach for the diagnosis of head and neck squamous cell carcinomas caused by human papilloma virus (HPV+HNSCC) demonstrated improved accuracy, reduced cost, and a shorter time to diagnosis compared to the current clinical workup and could become the method of choice in the future. More...
13 Dec 2021
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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