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Molecular Diagnostics

Image: The Variant II Turbo Hemoglobin Testing System combines High Performance Liquid Chromatography (HPLC) precise and variant detection with fast throughput to provide a comprehensive solution for HbA1c testing (Photo courtesy of Bio-Rad).

Monogenic Hypercholesterolemia Increases Cardiovascular Disease Risk

 Monogenic familial hypercholesterolemia (FH) is associated with lifelong elevations in low-density lipoprotein cholesterol (LDL-C) levels and increased risk of atherosclerotic cardiovascular disease (CVD). More...
03 Mar 2020
Image: Peripheral blood smear from a patient with myelodysplastic syndrome showing macrocytic and hyperchromic anemia (cross), hypersegmented neutrophil (arrow) and moderate thrombocytopenia (Photo courtesy of Jong-Hwa Kim, MD, PhD).

Leukemic Stem Cell Score Predicts Myelodysplastic Syndrome Prognosis

 Myelodysplastic syndromes (MDS) are clonal myeloid malignancies arising from hematopoietic stem cells (HSCs), which are characterized by bone marrow (BM) ineffective hematopoiesis, peripheral blood cytopenias, and a propensity to transform to acute myeloid leukemia (AML). More...
03 Mar 2020
Image: MicroRNA miR-122 secondary structure and sequence conservation (Photo courtesy of Wikimedia Commons)

Identification of a MicroRNA Biomarker Linked to a Childhood Liver Disease

 A study of infants and young children suffering from intestinal failure-associated liver disease found that levels of the microRNA biomarker miR-122 decreased following successful fish oil treatment. More...
03 Mar 2020
Image: The ClearCell FX1 novel platform for detect circulating tumor DNA from blood samples (Photo courtesy of Explorea s.r.o.).

Heterogeneous Populations of Melanoma Circulating Tumor Cells Detected

 Circulating tumor cells (CTCs) can be assessed through a minimally invasive blood sample with potential utility as a predictive, prognostic and pharmacodynamic biomarker. The large heterogeneity of melanoma CTCs has hindered their detection and clinical application. More...
02 Mar 2020
Image: Photomicrograph of a pancreatic islet, showing insulin-producing beta cells (Photo courtesy of Wikimedia Commons)

Researchers Identify Genes Linked to the Development of Monogenic Diabetes

 By studying a well controlled group of young Lithuanian diabetes patients, researchers were able to identify genes linked to the development of the rare monogenic form of diabetes. More...
02 Mar 2020
Image: MACS Technology is a fast and gentle method for the isolation of viable and functionally active cells by magnetic labeling (Photo courtesy of University of Konstanz).

Fetal Cell-Based NIPT Demonstrated by Droplet Digital PCR

 Noninvasive testing techniques are often used for fetal diagnosis of genetic abnormalities, but are limited by certain characteristics, including non-informative results. Thus, novel methods of noninvasive definitive diagnosis of fetal genetic abnormalities are needed. More...
27 Feb 2020
Image: The ID NOW Influenza A & B 2 assay delivers molecular flu results in 13 minutes or less on the unique ID NOW platform; making it significantly faster than other molecular methods and more accurate than conventional rapid tests (Photo courtesy of Abbott Laboratories).

Point-Of-Care Molecular Tests Compared for Pediatric Influenza

 Respiratory infection by influenza (Flu) is capable of causing severe illness resulting in hospitalization and death in young children and the elderly. Early diagnosis of influenza virus is critical for patient management, infection control, and reduction of health care costs. More...
27 Feb 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.