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Molecular Diagnostics

The MiSeqDx System is the first FDA-regulated, CE-IVD-marked, NGS platform for in vitro diagnostic (IVD) testing (Photo courtesy of Illumina)

Insulin Resistance and T2D Associated With Gut Microbial Diversity

Type 2 diabetes (T2D) is a common complex metabolic disorder. Currently, more than 380 million people live with type 2 diabetes globally, and this number is expected to increase to more than 550 million by 2030. More...
13 Aug 2021
The SuperScript III Reverse Transcriptase (RT) kit provides increased specificity with gene-specific primers (GSPs) and the highest cDNA yield of all RTs (Photo courtesy of Thermo Fisher Scientific).

Molecular Assays Compared For MRD Detection In B-ALL

B-cell precursor acute lymphoblastic leukemia (B-ALL) is the most common malignancy in children, and it may be associated with gene alterations that regulate B-cell development. The prognostic significance of minimal residual disease (MRD) in children with acute lymphoblastic leukemia (ALL) has been demonstrated. More...
11 Aug 2021
Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease (Photo courtesy of Massachusetts General Hospital)

Microbiome and Metabolic Features Tied to IBD Treatment Response

Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine. Crohn's disease and ulcerative colitis are the principal types of inflammatory bowel disease. More...
06 Aug 2021
Real-world data support the clinical utility of the Decipher Prostate Biopsy Genomic Test for determining prostate cancer treatment options (Photo courtesy of Clinical Lab Products)

Genomic Test Aids in Determining Prostate Cancer Treatment Options

A clinical study has confirmed that a commercially available genomic test was useful for identifying which prostate cancer patients would benefit from more immediate and aggressive treatment. More...
06 Aug 2021
Typical RNA sequencing workflow (Photo courtesy of Wikimedia Commons)

Advanced Sequencing Techniques Determine Cancer Genome Variants in Young Patients

A recent paper described a three-platform sequencing approach, including whole genome (WGS), exome, and RNA sequencing, that was used to examine tumor and germline genomes from prospectively identified children with newly diagnosed or relapsed/refractory cancers. More...
03 Aug 2021
Image: Immunoscreening of TIA antigens by SEREX. Bacterial proteins including phage cDNA products were blotted on nitrocellulose membranes and reacted with the sera of patients with transient ischemic attack (TIA); arrows indicate positive phage clones (Photo courtesy of Chiba University)

ALDOA and FH4 Antibodies Associated with Cerebrovascular Disease

Ischemic stroke, including transient ischemic attack (TIA) and cerebral infarction (CI), is the most globally recognized cerebrovascular disorder, and is a serious health problem in the aging society. CI is an episode of neurological dysfunction caused by focal brain infarction, often resulting in fatality and disability. Patients with TIA are at a high risk of CI. More...
28 Jul 2021
Image: Primary angle closure glaucoma can cause permanent blindness if not treated quickly. A highly sensitive genetic test has been developed (Photo courtesy of Flinders University)

Highly Sensitive Genetic Test for Glaucoma Developed

In open-angle glaucoma, the angle in the eye where the iris meets the cornea is as wide and open as it should be, but the eye’s drainage canals become clogged over time, causing an increase in internal eye pressure and subsequent damage to the optic nerve. More...
28 Jul 2021
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.