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Molecular Diagnostics

Image: Crystal structure of IL-6 (Photo courtesy of Wikimedia Commons)

Elevated Cytokine Levels Linked to Future Development of Myocardial Infarction

Elevated levels of the plasma biomarkers interleukin-6 (IL-6) and the IL-6 binary complex have been linked to the increased risk of myocardial infarction (MI) found in smokers and individuals with hypertension. More...
17 May 2021
Image: An assay platform that combines robust, high-efficiency biochemistry at the front-end, with next-generation sequencing, and a machine-learning augmented bioinformatics pipeline provides information that can help advanced cancer patients obtain the right treatment (Photo courtesy of Guardant Health, Inc.)

New Blood Test Promises Biopsy-Free Colon Cancer Diagnosis

A newly developed liquid biopsy test detects persistent circulating tumor DNA (ctDNA) after curative surgery and can identify patients with minimal residual disease (MRD) who will ultimately relapse. More...
11 May 2021
Image: Photograph of the novel capsule-based smell test (Photo courtesy of Queen Mary University of London)

A Novel Capsule-Based Smell Test for Diagnosis of Neurological and Respiratory Diseases

To aid in diagnosing diseases where loss of the sense of smell is a symptom, such as in chronic neurological conditions like Parkinson's and Alzheimer's diseases and in acute respiratory infections such as that caused by COVID-19, a team of researchers at Queen Mary University of London (United Kingdom) developed a novel smell testing kit based on capsules of aromatic oils placed between two strips of single-sided tape. More...
10 May 2021
Image: The Hamamatsu Photonics Nanozoomer 1 Digital Slide Scanner (Photo courtesy of University of Adelaide)

Genetic Background and Clinicopathologic Features Established for Adult-Onset Nephronophthisis

Nephronophthisis (NPH) is a genetic disorder of the kidneys which mainly affects children. It is classified as a medullary cystic kidney disease. The disorder is inherited in an autosomal recessive fashion and, although rare, is the most common genetic cause of childhood kidney failure. More...
06 May 2021
Image: The AMPLIX real-time polymerase chain reaction system (Photo courtesy of Biosynex)

LAMP Assay Developed to Diagnose High HBV DNA Levels

Worldwide, 257 million people are chronically infected with hepatitis B virus (HBV) and 887,000 annually die from cirrhosis or liver cancer. Since more than 95% of HBV-infected people live in low-income and middle-income countries (LMICs) and only 12-25% of infected people are eligible for anti-HBV therapy. More...
05 May 2021
Image: EN2: a novel prostate cancer biomarker (Photo courtesy of Future Medicine)

Protein Biomarker Increases Sensitivity of a Urine-based Prostate Cancer Test

A team of British researchers increased the sensitivity of an advanced RNA and DNA biomarker-based urine test for diagnosis of aggressive prostate cancer by including the measurement of a protein biomarker, which is expected to reduce the number of unnecessary biopsies performed every year by up to 35%. More...
05 May 2021
Image: Micrograph of a colorectal adenocarcinoma metastasis to a lymph node. The cancer (forming glands) is seen at the center-top. Adipose tissue is present on the upper right (Photo courtesy of Wikimedia Commons)

Blood-based Liquid Biopsy Detects Lymph Node Metastasis in Colorectal Cancer Patients

A recent paper described a novel, noninvasive liquid biopsy test for detection of lymph node metastasis in individuals with high-risk T1 colorectal cancer. More...
04 May 2021
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.