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Medica 2025
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Molecular Diagnostics

Image: The RNA of the coronavirus was extracted from the patient sample, which then underwent reverse transcription, gene amplification, and detection through nanoPCR to diagnose the COVID-19 infection. For rapid gene amplification and detection, magneto-plasmonic nanoparticles (MPNs) were used to facilitate the temperature change cycle of the existing RT-PCR at high speed. Finally, a magnetic field separated the MPN, and the fluorescent signal of the amplified DNA was detected (Photo courtesy of Institute for Basic Science, Korea)

Rapid Decentralized Testing for Diagnosis of COVID-19

A novel "nanoPCR" technique enables diagnosis of COVID-19 infections in less than 20 minutes with the accuracy of the current PCR method. More...
15 Dec 2020
Image: A `heat map` of the brain of a person with mild Alzheimer's dementia shows where tau protein has accumulated, with areas of higher density in red and orange, and lower density in green and blue (Photo courtesy of Tammie Benzinger/Knight ADRC)

Microtubule Binding Region of Tau Protein Is a Biomarker for Diagnosis of Alzheimer’s Disease

A recent paper highlighted the presence and potential utility of MTBR-tau species as biomarkers for diagnosis of Alzheimer’s disease. More...
14 Dec 2020
Image: An artist`s conception of nanodiamonds used for in vitro diagnostics (Photo courtesy of Ella Maru Studio, University College London)

Nanodiamonds Dramatically Boost Immunoassay Sensitivity

Incorporation of a specific class of nanodiamond into lateral flow immunoassays was shown to increase the sensitivity of this method by at least five orders of magnitude. More...
08 Dec 2020
Image: Abnormal accumulation of tau protein in neuronal cell bodies (arrow) and neuronal extensions (arrowhead) in the neocortex of a patient who had died with Alzheimer`s disease (Photo courtesy of Wikimedia Commons)

Some Phosphorylated Tau Proteins Indicate Alzheimer’s Disease Prior to Appearance of Cognitive Impairment

Determination of some specific types of phosphorylated tau proteins enables detection of Alzheimer’s disease before development of cognitive impairment. More...
08 Dec 2020
Image: Rare genetic differences play vital role in regulating blood pressure (Photo courtesy of British Heart Foundation).

Rare Variants Associated with Blood Pressure Regulation

Genes likely play some role in high blood pressure, heart disease, and other related conditions. However, it is also likely that people with a family history of high blood pressure share common environmental and other potential factors that increase their risk. More...
07 Dec 2020
Image: A recently developed device enables faster testing of antibiotic-resistant bacteria (Photo courtesy of Dr. Seokheun `Sean` Choi)

Fast Antibacterial Susceptibility Testing by Measuring Electron Transfer Metabolism

A recently developed device facilitates bacterial antibiotics susceptibility testing by measuring the effect of these drugs on bacterial electron transfer metabolism. More...
07 Dec 2020
Image: The Tapestri Platform is the first and only single-cell multi-omics platform that is capable of simultaneously providing both genotype and phenotype data from the same cell, across thousands of cells (Photo courtesy of Mission Bio).

Single-Cell Analysis Elucidates Mutation Patterns in Myeloid Malignancies

Myeloid malignancies are clonal diseases of hematopoietic stem or progenitor cells. Myeloid malignancies, including acute myeloid leukemia (AML), arise from the expansion of these hematopoietic stem and progenitor cells that acquire somatic mutations. More...
01 Dec 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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