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Molecular Diagnostics

Image: Circulating tumor DNA (ctDNA) is found in the bloodstream and refers to DNA that comes from cancerous cells and tumors. The LiquidHALLMARK assay, a liquid biopsy test, tracks treatment-based ctDNA changes (Photo courtesy of Jonathan Bailey, National Human Genome Research Institute)

Liquid Biopsy Test Tracks Treatment-Based ctDNA Changes

Metastatic or unresectable disease is identified in approximately 20% of patients presenting with invasive urothelial cancer. In addition, up to 50% of patients will develop metastases following radical cystectomy for clinically localized disease. More...
06 Oct 2021
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New State-of-the-Art, Ultrasensitive Blood Test to Transform Detection of Brain Damage and Poor Prognosis After Head Injury

A new study has used a state-of-the-art blood test to track damage to the brain in people who have sustained traumatic brain injury (TBI). More...
06 Oct 2021
Image: The DELFI blood test identifies lung cancer using artificial intelligence to detect unique patterns in the fragmentation of DNA shed from cancer cells compared to normal profiles (Photo courtesy of Carolyn Hruban)

A Blood-Based Liquid Biopsy Combined with Machine Learning for Early Lung Cancer Diagnosis

A novel liquid biopsy that collects fragments of circulating tumor DNA combined with advanced machine learning technology was able to detect over 90% of lung cancers in samples from nearly 800 individuals with and without the disease. More...
05 Oct 2021
Image: The Agilent TapeStation system is an established automated electrophoresis tool for DNA and RNA sample quality control (Photo courtesy of Agilent Technologies)

Benign Hypertension-Causing Tumors Linked to Somatic Co-Driver Mutations

Most aldosterone-producing adenomas (APAs) have gain-of-function somatic mutations of ion channels or transporters. However, their frequency in aldosterone-producing cell clusters of normal adrenal gland suggests a requirement for co-driver mutations in APAs. More...
05 Oct 2021
Image: Blood smear from a P. falciparum culture. Several red blood cells have ring stages inside them. Close to the center is a schizont and on the left a trophozoite (Photo courtesy of Wikimedia Commons)

WHO Warning: Rapid Tests Misdiagnose Many Cases of P. falciparum Malaria in Africa

A pair of mutations, which result in deletion of the Plasmodium falciparum histidine-rich protein 2 (HRP2), render the malaria parasite invisible to the most commonly used rapid diagnostic tests. More...
05 Oct 2021
Image: Next Generation Phenotyping Platform from Selux (Photo courtesy of Selux Diagnostics, Inc.)

Next Generation Rapid Antibiotic Susceptibility Testing (AST) Platform Granted FDA Breakthrough Device Designation

Selux Diagnostics, Inc.’s (Boston, MA, USA) Next Generation Phenotyping (NGP) platform has received Breakthrough Device Designation from the U.S. Food and Drug Administration (FDA) for positive blood culture and sterile body fluid samples. More...
05 Oct 2021
Image: Photomicrograph of a bone marrow smear from a patient with hemophagocytic lymphohistiocytosis, showing foamy macrophages engulfing mature and precursor erythrocytes (arrow) (Photo courtesy of Ismail Hader, MD, FACP)

IFN-γ Signature Distinguishes Pediatric Hemophagocytic Lymphohistiocytosis from Sepsis and SIRS

Hemophagocytic lymphohistiocytosis (HLH), severe sepsis, and persistent systemic inflammatory response syndrome are all conditions defined by excessive immune activation that may progress rapidly and are associated high risk of death without early introduction of appropriate therapy. More...
04 Oct 2021
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