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Molecular Diagnostics

Image: A Cas12a2 protein unzips a DNA double helix, allowing it to cut the single strands of DNA (Photo courtesy of University of Texas at Austin)

CRISPR Protein Could Yield New Tests for Many Viruses

In a first for the genetic toolset known as CRISPR, a recently discovered protein has been found to act as a kind of multipurpose self-destruct system for bacteria, capable of degrading single-stranded RNA, single-stranded DNA and double-stranded DNA. With its abilities to target so many types of genetic material, the discovery holds potential for the development of new inexpensive and highly sensitive at-home diagnostic tests for a wide range of infectious diseases. More...
05 Jan 2023
Image: The MicroScan autoSCAN-4 semi-automated system provides simplified ID/AST testing in a highly reliable and affordable package and confirmed the results of the study (Photo courtesy of Beckman Coulter)

Nanopore Sequencing Detect Pathogens in Knee Periprosthetic Joint Infection

The number of total knee arthroplasty (TKA) is currently increasing substantially, and it is expected to increase more than two times in the next decade worldwide. With the increasing number of TKA, the number of prosthetic joint infections (PJIs) is also increasing, and PJI is currently regarded as the most common etiology for revision TKA. More...
05 Jan 2023
Image: The OverC MCDBT has been granted Breakthrough Device Designation by the US FDA (Photo courtesy of Burning Rock)

Multi-Cancer Detection Blood Test to Enable Early Diagnosis and Treatment

The US Food and Drug Administration (FDA) has granted Breakthrough Device Designation to a Multi-Cancer Detection Blood Test (MCDBT) that is intended for early detection of multiple cancer types (esophageal, liver, lung, ovarian, and pancreatic cancers) in adults of either sex, aged 50-75 years old, at average risk for cancer. More...
04 Jan 2023
Image: The test demonstrated 83% sensitivity for the detection of colorectal cancer with specificity of 90% (Photo courtesy of Guardant Health)

Blood-Based Screening Test for Colorectal Cancer Demonstrates Strong Clinical Performance

A blood test for the detection of colorectal cancer (CRC) has demonstrated 83% sensitivity with specificity of 90%, paving the way for the first potential US FDA-approved blood test for CRC screening. More...
03 Jan 2023
Image: The liquid biopsy test diagnoses brain tumors where conventional biopsy is not possible (Photo courtesy of Datar Cancer Genetics)

Blood Test Helps Diagnose Inaccessible Brain Tumors

Presently, no blood test is available for diagnosing brain cancers, and doctors have to rely on complex surgical procedures to obtain tumor tissue for histopathological evaluation. Now, a new blood test can detect the cells released from the brain tumor that are extremely rare and hard to detect, enabling early diagnosis and treatment. More...
03 Jan 2023
Image: Surface treatment of microarrays used for clinical diagnosis (Photo courtesy of Yamaguchi University)

Clinical Microarray System Developed for Genetic Analysis Screening

In precision medicine, preoperative or postoperative genetic testing can be used to stratify patients according to disease states and select appropriate drugs, enabling efficient delivery of personalized treatment. More...
02 Jan 2023
Image: The Lena Q51 leukemia diagnostic test will be launched in January 2023 (Photo courtesy of Alercell)

First Leukemia Diagnostic Test Based on DNA Sequencing Detects up To 51 Gene Mutations

Until 2022 the only leukemia tests done could detect two gene mutations. Now, a new leukemia diagnostic test is capable of detecting 51 gene mutations, marking a significant technological and medical advancement. More...
02 Jan 2023
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.