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Molecular Diagnostics

Image: Micrograph of imaging experiment showing C4 (green) located at the synapses (red and white) of cultured primary human neurons (cell bodies in blue) (Photo courtesy of Heather de Rivera, McCarroll Laboratory).

First-Ever Gene Identified with Biological Origin of Schizophrenia

In a landmark study, researchers have identified mutants of the complement component 4 gene that are strongly associated with the risk of developing schizophrenia.   More...
07 Feb 2016
Image: Histopathology of epithelial ovarian cancer (Photo courtesy of the Human Protein Atlas).

Inherited Gene Mutation Leads to Ovarian Cancer

Women who carry an inherited fault in a certain gene are more than three times more likely to develop epithelial ovarian cancer than those without the mutation.   More...
03 Feb 2016
Image: The Xpert Ebola Assay cartridge (Photo courtesy of Cepheid Inc.).

Rapid Diagnostic Assay for Ebola Field Tested

Rapid diagnostic methods are essential in control of Ebola outbreaks and lead to timely isolation of cases and improved epidemiologic surveillance, but diagnosis during Ebola outbreaks in West Africa has relied on PCRs performed in laboratories outside the region.   More...
02 Feb 2016
Image: Molecular surface of the capsid of human rhinovirus, one of the viruses which cause acute respiratory infections (Photo courtesy of A. J. Cann).

Blood Test Could Identify Which Patients Need Antibiotics

Acute respiratory infections caused by bacterial or viral pathogens are among the most common reasons for seeking medical car and despite improvements in pathogen-based diagnostics, most patients receive inappropriate antibiotics.  More...
31 Jan 2016
Image: Human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) identified by in situ hybridization (Photo courtesy of Jennifer L. Hunt, MD, and Wikimedia).

Oral HPVs Associated with Risk of Incident Head and Neck Cancers

A prospective study suggests that detection in the oral cavity of certain human papillomavirus types is associated with higher risk of incident head and neck squamous cell carcinoma, suggesting that the role of HPV in HNSCC may be even more important than currently recognized.  More...
31 Jan 2016
Image: T1 weighted sagittal cervical spine MRI showing degenerative disc disease, osteophytes, and osteoarthritis of C5-C6 (Image courtesy of Wikimedia).

New Approach to Aid in Diagnosing Lower Back Pain Revealed

In a clinical study, scientists have identified a potential new method, based on biochemical profiling of serum for circulating cytokines, that may assist in refining personalized diagnoses of disc diseases and possibly even in distinguishing between severe and mild conditions.   More...
27 Jan 2016
Image: Bone marrow aspirate of acute myeloid leukemia: Azurophilic granularity can be seen in essentially all of the blasts and variability in nuclear size and contour is observable (Photo courtesy of Dr. John Lazarchick, MD).

Early and Accurate Prediction of Leukemia Made Possible

Acute myeloid leukemia is the most common type of leukemia in adults and recent studies demonstrate that early and accurate prediction of this aggressive cancer is possible how it will develop in individuals.  More...
25 Jan 2016
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