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Molecular Diagnostics

Image: New study shows that blood testing by targeted-NGS of extracted cfDNA could help match cancer patients with the most appropriate targeted therapy and to simply and quickly monitor response to treatment (Photo courtesy of Cancer Research UK).

Blood Test Could Match and Monitor Cancer Patients and Treatment

Researchers have found that new generation sequencing of circulating cell-free DNA in blood plasma could help successfully pair cancer patients with the most suitable therapy and track tumor progression to assess treatment effectiveness.  More...
01 Nov 2015
Image: The HiSeq 2500 ultra-high-throughput sequencing system (Photo courtesy of Illumina).

Novel Diagnostic Technology Rapidly Identifies Cancer Source

A substantial proportion of cancer cases present with a metastatic tumor and require further testing to determine the primary site; many of these are never fully diagnosed and remain cancer of unknown primary origin.  More...
28 Oct 2015
Image: The IONA test for the screening plasma for trisomies 21, 18 or 13 (Photo courtesy of Premaitha Health plc).

Noninvasive Prenatal Screening Test Validated for Trisomies

Diagnosis of fetal aneuploidies relies on invasive testing by chorionic villous sampling or amniocentesis in pregnancies that are identified by screening to be at high-risk for such aneuploidies.  More...
28 Oct 2015
Image: A schematic diagram of a new method that rapidly analyzes the RNA (green strands) of HIV for mutations (red dot) that convey drug resistance. The system does not require transcription of RNA to DNA, as current technologies do, and works within one solution (purple droplet) (Photo courtesy of Dr. Lei Zhang, Brown University).

One-Tube RNA Ligation and Amplification Method for Rapid Detection of Drug Resistant HIV

By not requiring transcription of RNA to DNA, a novel one-tube method allows the rapid detection of drug resistant strains of HIV.  More...
28 Oct 2015
Image: The 3M Integrated Cycler with assay kits (Photo courtesy of Focus Diagnostics).

Simplexa Direct Test Includes 53 New Virus Strains

The Simplexa test kit for select virus strains can detect a total of 92 influenza and respiratory syncytial virus virus strains, more than any other officially cleared molecular test kit.  More...
20 Oct 2015
Image: Ciliary ultrastructure on the right from a patient with primary ciliary dyskinesia (PCD) showing the absence of outer and inner dynein arms and on the left normal cilium from a healthy individual in which both inner and outer dynein arms can clearly identified (Photo courtesy of Dr. J. Carson, PhD).

Test Menu Expanded to Include Hundreds of New Genes

A genetic information company has announced that it has more than doubled the size of its genetic testing platform to include more than 600 genes and will release the new content between now and the end of 2015.  More...
20 Oct 2015
Image: In Roche’s Cervical Cancer Screening Portfolio, the “CINtec p16 Histology” immunohistochemistry assay detects p16-INK4a in cervical biopsy preparations. The figure illustrates that in cells with transforming HPV infections, HPV viral oncoprotein E7 impairs the function of pRB, disrupting its ability to bind to E2F. This leads to deregulated cell proliferation, genetic instability, and p16 over-expression detectible by immunohistochemistry staining (Image courtesy of Ventana, of Roche).

Screening Portfolio Protects Patients from Cervical Cancer and Overtreatment

A new portfolio of clinically validated genetic and pathology tests for human papillomavirus cervical cancer screening and diagnosis helps identify women at high risk of developing this highly preventable disease, which is nevertheless still classified as the 4th most frequent cancer in women—530,000 new cases annually, of which about half the patients die.  More...
20 Oct 2015
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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