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Molecular Diagnostics

Image: An MRI scan of a human brain (Photo courtesy of the Institute of Cancer Research, London).

Cancer Study Reveals Insights to Causes and Inherited Risk

In a largest-to-date genomics study of brain cancer, researchers have uncovered treasure trove of information about genetics underlying the most common form of brain cancer – glioma. They were able to identify mutations that increase susceptibility, and assess more specific associations with developing one or the other of the two main glioma subtypes. More...
04 Apr 2017
Image: A genetic variant within the gene for protein tyrosine phosphatase receptor-type delta (PTPRD) has been associated to susceptibility to neurofibrillary tangles, which are thought to be more closely related to memory decline than other forms of aging-related brain pathologies (Photo courtesy of Rush University).

Gene Discovered Associated with Aging Brain Pathologies

Investigators have discovered a gene associated with susceptibility to the common Tau form of brain pathology that accumulates in several different conditions, including Alzheimer’s disease, certain forms of dementia, and Parkinsonian syndromes, as well as chronic traumatic encephalopathy that occurs with repeated head injuries. The gene and its product may serve as a marker for loss of brain function with advancing age, and as a potential drug therapy target. More...
04 Apr 2017
Image: Controlling magnetic nanoparticles through a microfluidic chip – produced by the rapid prototyping method – with the aid of magnets that are arranged above and below the microfluidic chip (Photo courtesy of the Fraunhofer Institute for Cell Therapy & Immunology).

Lab-on-a-Chip Platform Designed for Detection of Pathogens

A team of German bioengineers has developed an integrated and automated lab-on-a-chip platform for sample preparation and nucleic acid-based detection of pathogens in various liquid media. More...
04 Apr 2017
Image: The CancerLocator method focuses on DNA methylation, which is depicted in this image. The two white spheres represent methyl groups bound to two cytosine nucleotide molecules (Photo courtesy of Wikimedia Commons).

Blood Test Analysis Identifies Early-Stage Tumors

The development of a blood test that screens for methylated DNA from tumor cells may herald an era of simpler and more precise cancer diagnostics. More...
04 Apr 2017
Image: A prototype of the mobile diagnostic device developed by Sandia scientists and engineers for rapid detection of Zika and related viruses (Photo courtesy of Sandia National Laboratories / Randy Wong).

Mobile Device Rapidly Detects Zika and Related Viruses

A team of biologists and engineers have developed a smartphone-controlled, battery-operated, low-weight diagnostic technology that costs as little as USD 100 and can detect Zika, dengue, and chikungunya viruses within 30 minutes. The same platform can also be adapted to detect other human or animal pathogens. More...
31 Mar 2017
Image: New findings suggest that certain circulation microRNAs could serve as markers to help identify patients less likely to benefit from ablation therapy (Photo courtesy of Intermountain Medical Center).

Markers Predict Recurrence of Atrial Fibrillation after Ablation

Study suggests that certain circulating microRNA molecules are associated with the recurrence of the abnormal erratic heartbeats in some patients after ablation procedure, potentially providing markers that may help identify such patients in advance, as ablation therapy carries some risks and is expensive. More...
30 Mar 2017
Image: A micrograph of prostatic adenocarcinoma (conventional, acinar type) with perineural invasion. Prostate biopsy, H&E stain (Photo courtesy of Wikimedia).

Gene Mutations Associated with Aggressive Prostate Cancer

An international study has identified inherited genomic DNA mutations in the Kallikrein 6 (KLK6) gene region that are connected to a predisposition for some men to develop aggressive prostate cancer (PC). More...
28 Mar 2017
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