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Molecular Diagnostics

Image: The structure of the SEMA4D protein (Photo courtesy of Wikimedia Commons).

Mutation Linked to Obesity Identified in Genome Study

Results obtained during what was probably the first genome-wide association study (GWAS) for body mass index (BMI) to be conducted in continental Africa identified a gene, carried by about 1% of West Africans, linked to hereditary obesity. More...
21 Mar 2017
Image: Researchers say those who have a genetic disposition for storing fat deposits primarily at their waistline are at a higher risk of developing diabetes and coronary heart disease (Photo courtesy of Massachusetts General Hospital).

Body Type Can Increase Risk of Heart Disease and Diabetes

Researchers have identified a pattern of gene variants associated with an “apple-shaped” body type, in which weight is deposited around the abdomen rather than in the hips and thighs, increases risk for type 2 diabetes and coronary heart disease, as well as the incidence of several cardiovascular risk factors. More...
17 Mar 2017
Image: A scanning electron micrograph (SEM) of ovarian cancer cells (Photo courtesy of Steve Gschmeissner / SPL).

High Levels of Biomarker Protein Indicate Poor Prognosis for Cancer Patients

The surface biomarker protein CD151 has been linked to a poor prognosis for patients suffering from high-grade serous ovarian cancer (HGSC), the most common and lethal subtype of the disease. More...
15 Mar 2017

Test Markers Identify Cancer DNA and Pinpoint Tumor Location

A team of molecular geneticists has developed a diagnostic tool that identifies circulating cancer DNA and determines the organ in which the tumor is located. More...
15 Mar 2017
Image: A microscopic view of a colon cancer section (Photo courtesy of the IDIBELL-Bellvitge Biomedical Research Institute).

Colorectal Cancer Predicted by Merging Risk Factors

A team of Spanish cancer researchers has devised a method for predicting risk of developing colorectal cancer (CRC) that combines life style choices, family background, and genetic data. More...
14 Mar 2017
Image: Two views, one rotated 90 degrees with respect to the other, of the amino acid chains comprising secretory IgA1. Colors are: H-chains (blue and light blue), L-chains (red and light red), J-chain (magenta) and the secretory component (yellow) (Photo courtesy of Wikimedia Commons).

Study Identifies Genes Linked to Autoimmune Kidney Disease

A pair of genes linked to serum levels of the defective immunoglobulin galactose-deficient IgA1 has been identified during a genome-wide association study (GWAS) and may serve as biomarkers to help diagnose the autoimmune kidney disease IgA nephropathy (IgAN), or Berger's disease. More...
14 Mar 2017
Image: Researchers have identified two genes that are associated with an increased risk of developing gallbladder cancer (Photo courtesy of Medscape).

Two Genes Linked to Risk of Gallbladder Cancer

By performing a genome-wide scan (GWAS) of gallbladder cancer patients and hospital visitor controls, a team of researchers identified two genes that were associated with a small but definite risk of developing the disease. More...
14 Mar 2017
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