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Molecular Diagnostics

Image: The FLUOstar Omega multi-mode microplate reader. A newly developed prion seeding assay called Real-Time Quaking Induced Conversion assay (RT-QuIC), scientists can now measure prion seeding at lower levels and in less than a few days in standard 96-well microplates (Photo courtesy of BMG Labtech).

Prion Protein Found in Skin of CJD Patients

Creutzfeldt-Jakob disease (CJD) is an incurable, and ultimately fatal, transmissible, neurodegenerative disorder in the family of prion diseases. Prion diseases originate when normally harmless prion protein molecules become abnormal and gather in clusters and filaments in the human body and brain. More...
07 Dec 2017
Image: The ThermoQuest Trace GC 2000 gas chromatography mass spectroscopy (GCMS) platform (Photo courtesy of Strona Polimerka).

Metabolites Altered in Chronic Kidney Disease

Chronic kidney disease (CKD) is an important public health problem with a high prevalence worldwide, from 10% to14% of the general population, and strongly increased age-standardized death rate, yet, there is a paucity of effective treatment options. More...
07 Dec 2017
Image: A bone marrow aspirate from a patient with acute myeloid leukemia (Photo courtesy of Cytogenetic Oncology Laboratory).

HLF-Gene Controls Generation of Immune System

Blood stem cells give rise to all of the blood cells, the red blood cells that transport oxygen, the platelets that enable blood coagulation, and our immune cells that protect us from infections. More...
06 Dec 2017
Image: A representation of the molecular structure of the Indoleamine 2,3 dioxygenase-1 (IDO-1) protein (Photo courtesy of Wikimedia Commons).

Immune Tolerance Level Predicts Leukemia Outcome

Measurement of messenger RNA (mRNA) encoding an enzyme that augments tumor-induced immune tolerance was shown to be predicative of the outcome for patients with leukemia. More...
04 Dec 2017
Image: An ancient bacterial enzyme (grey) crawls along a tangled strand of RNA (orange), creating a complimentary strand of DNA (blue). This enzyme, called GsI-IIC RT, and part of a group of enzymes known as TGIRTs, have novel properties that make it easier to detect RNA biomarkers from cancer and other disorders (Photo courtesy of the University of Texas at Austin).

Enzyme Boosts Power of Liquid Biopsies to Detect Cancers

A new tool has been developed for liquid biopsy that can detect RNA biomarkers from cancer cells in a patient's blood much more accurately and completely than other existing methods. This could soon provide doctors with a more complete picture of an individual's disease. More...
29 Nov 2017
Image: A histopathology of a brain showing metastatic lesions from a patient with non-small cell lung cancer (Photo courtesy of Peter Anderson).

CSF Analyzed in Lung Cancer with Brain Metastases

The analysis of mutations in cerebrospinal fluid of lung cancer patients with brain metastases has been explored. Tumor tissue from brain metastasis is difficult to obtain and therefore less invasive methods are needed to identify and monitor the presence of known actionable mutations. More...
29 Nov 2017
Image: Sample application for a VeriStrat assay. The assay provides highly sensitive results in 72 hours for non-small cell lung cancer (NSCLC) patients (Photo courtesy of Biodesix).

Automated RNA Extraction from Plasma Analytically Validated

A novel, automated method for extracting circulating RNA from plasma has been demonstrated and the method performed equivalently or better than the established manual method that is currently used. More...
28 Nov 2017
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