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Molecular Diagnostics

Image: The ability of cancer cells to move and spread depends on actin-rich core structures such as the podosomes (yellow) shown here in melanoma cells. Cell nuclei (blue), actin (red), and an actin regulator (green) are also shown (Photo courtesy of Julio C. Valencia and Daniel Mietchken, and Wikimedia).

Association Found Between MC1R Variant and Melanoma Risk

A new study finds that melanocortin-1 receptor is a risk factor for melanoma independent of sun exposure, supporting recent mouse model research that showed a UV radiation-independent pathway for development of melanoma and highlighting the importance of the genetic background of the host.  More...
12 Apr 2016
Image: Schematic diagram of a transrectal prostate biopsy (Photo courtesy National Cancer Institute).

Prostate Needle Biopsy Biomarker Predicts Tumor Aggressiveness

A new study demonstrates the ability to measure and evaluate biomarkers from ribonucleic acid expression data obtained from prostate needle biopsies. The data demonstrate a high concordance in the genomic signatures between needle biopsy samples and post-prostatectomy tissue samples.   More...
11 Apr 2016
DIASOURCE (A Biovendor Company)
Image: Gross appearance of an opened colectomy specimen containing two adenomatous polyps and one invasive colorectal carcinoma (Photo courtesy of Emmanuelm).

Gene Test Identifies Patients with High Risk Colon Cancer

Proprietary microarray-based gene signature marker can identify patients' recurrence risk within five years after surgery and guides adjuvant chemotherapy treatment decisions. Colon cancer is the second leading cause of cancer mortality among men and women in the USA and the five-year survival rate for individuals with colon cancer is 64.9%.   More...
11 Apr 2016
Image: The NextSeq 500 Series desktop sequencing system (Photo courtesy of Illumina).

Improved “Liquid Biopsy” Technique Enhances Tumor DNA Detection

An improved method has been devised to significantly increase the sensitivity of a technique to identify and sequence DNA from cancer cells circulating in a person's blood. The hope is that such "liquid biopsies" of easily obtained blood samples could one day replace the need to surgically obtain tumor tissue for examination.  More...
10 Apr 2016
Image: Micrograph of pancreatic ductal adenocarcinoma (the most common type of pancreatic cancer) (Photo courtesy of Wikimedia Commons).

Establishment of Biomarker Panel May Lead to Rapid Tests for Early Diagnosis of Pancreatic Cancer

A panel comprising five genetic biomarkers was shown to accurately differentiate among tissues from pancreatic tumors and those taken from various non-malignant sources.  More...
10 Apr 2016
Image: Sarocladium kiliense after 10 days’ growth on Sabouraud-Dextrose Agar at 30 °C (Photo courtesy of Thunderhouse4-yuri).

Genomic Sequencing Identifies Deadly Bloodstream Infection

The differentiation between fungal infections originating from a single contaminated point source and those independently acquired from the environment is often difficult.  More...
06 Apr 2016
Image: Histopathology of a skin section from a patient with superficial spreading malignant melanoma (Photo courtesy of Profs. Leszek Wozniak and Krzysztof W. Zielinski).

Noncoding RNA Gene Linked to Malignant Melanoma

While a large share of the human genome has long been considered “junk DNA” because it does not contribute to protein coding, recent insights indicate that it does produce many noncoding ribonucleic acids that play important roles in essential biological processes and diseases.   More...
05 Apr 2016
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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