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Molecular Diagnostics

Low Levels of Protein Linked to Cognitive Decline

Alzheimer’s disease (AD) currently affects more than five million Americans. Amyloid plaques, long seen in the brains of people with AD are often blamed for the mental decline associated with the disease. More...
18 May 2017
Image: Immunofluorescence staining showing extension of prostatic adenocarcinoma into the bladder wall in a castration resistant prostate (Photo courtesy of the Institute of Cancer Research).

Test Predicts Benefit of Targeted Cancer Treatments

There is an urgent need to develop biomarker strategies to a priori identify castration-resistant prostate cancer (CRPC) patients who will derive minimal benefit from androgen receptor (AR) targeting and offer them an alternative treatment paradigm. More...
17 May 2017
Image: A biopsy from the sole of the foot showing a recovered granular layer and a layer of parakeratosis sandwiched between the old orthokeratotic stratum corneum and a re-established orthokeratotic layer (Photo courtesy of SAMJ).

Genomic Duplication Responsible for Rare Skin Disease

Through data analysis, ancestry mapping, genomic comparison, and international collaboration, researchers have identified the genetic mutation that causes the rare skin disease keratolytic winter erythema (KWE), or “Oudtshoorn skin,” in South African and Norwegian families. More...
15 May 2017
Image: Salmonella Typhi, the bacterium responsible for Typhoid fever (Photo courtesy of Animated Healthcare).

Typhoid Fever Victims Present Unique Metabolomic Profile

A panel of metabolic markers distinguishes patients with typhoid fever from others suffering from non-typhoid tropical fevers such as malaria. More...
15 May 2017
Image: Brain imaging studies have revealed differences in the volume of various brain regions between BD patients and healthy control subjects (Photo courtesy of Wikimedia Commons).

Child Biomarkers Linked to BD Parents

Biomarkers have been identified in children of patients with bipolar disorder that suggest that at the molecular level the disorder is linked to the process of apoptosis and related disturbance of mitochondrial function. More...
15 May 2017

Immune Response Differentiates Malaria from Other Infections

Malaria affects around 200 million people around the world but its non-specific symptoms, coupled with a lack of access to testing facilities, mean it is difficult to distinguish from other infectious diseases. More...
11 May 2017
Image: The Xpert HCV Viral Load cartridge, a quantitative test that provides on-demand molecular testing for confirmation of infection and monitoring of Hepatitis C virus (HCV) (Photo courtesy of Cepheid).

POC Test Advances Hepatitis C Diagnosis

A new test that enables diagnosis of hepatitis C infection in a single visit could improve access to early diagnosis, monitoring, and treatment service for some of the most vulnerable people in Australia and the world. More...
10 May 2017
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