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BioResearch

Inhibition of the Notch Signaling Pathway Blocks Lung Cancer Growth in Mouse Model

Spanish researchers have shown that gamma-secretase inhibitors, which block the Notch signaling pathway, effectively stopped the growth of human lung cancer in a mouse model of the disease. More...
28 Aug 2012

Novel Drug Cures Toxoplasmosis in Mouse Model

A novel, hi-tech drug that combines an antisense oligomer with a peptide able to penetrate most kinds of cell and nuclear membranes was found to dramatically lower the burden of Toxoplasma gondii parasites in a mouse model. More...
27 Aug 2012

Protein Implicated in Aberrant B-cell Survival in Transplant Disease

Ex vivo study finds that B-cells from patients with chronic graft vs. host disease are in a heightened metabolic state and are resistant to apoptosis compared to patients without cGVHD, and leads to identification of a key candidate target for development of more effective drug therapies. More...
27 Aug 2012

Novel Technique Improves Investigation of Interactions Between HIV and Malaria Parasite

A new video article describes a novel technique used to study the interactions between HIV-1 and Plasmodium falciparum in cultured human cells, allowing scientists to explore different parameters of coinfection by the two microbes. More...
27 Aug 2012

Ion Channel Protein TRPM7 Required for Breast Tumor Cell Metastasis in a Mouse Xenograft Model

A recent study identified the ion channel protein TRPM7 as being required for breast tumor cell metastasis. More...
23 Aug 2012

Immune Tolerance Induced by a Mixture of Cytokines and Dendritic Cells Enhances Gene Therapy

A study carried out in mice has demonstrated the potential for using primed immune dendritic cells to induce immune tolerance and reduce the possibility of rejection of therapeutic proteins administered by gene therapy. More...
23 Aug 2012

Successful Cancer Treatment Requires Blocking Chemotherapeutic Damage to Normal Tissues

Inhibitors of the transcription-regulating kinase CDK8 and its isoform CDK19 were found to prevent the sort of genomic damage suffered by normal tissues as a result of chemotherapy. More...
23 Aug 2012
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.