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BioResearch

Report Conveys Value and Threats of Nanotechnology Research

While scientists constantly increase their knowledge of biology and the surrounding world, all this newly gleaned information has the potential to advance healthcare, it is also possible that the same discoveries can also be used in ways that cause extensive havoc. More...
04 Feb 2013

New Technology Reduces Drug Development Costs

New technology based on cytochrome P450s proteins will speed up and reduce the cost of the development of new drugs and medicines. More...
04 Feb 2013
Image: The Thermo Scientific Cytomat 10 automated incubator (Photo courtesy of Thermo Fisher).

Advanced Incubation Solution Introduced for Cell-Based Research

An automated incubator and storage module provides superior cell growth and assay incubation and a reliable thermal decontamination routine. More...
31 Jan 2013

Treatment with Lipopolysaccharide Derivative Shows Promise in Alzheimer's Disease Mouse Model

Repeated systemic injections of the lipopolysaccharide derivative MPL significantly reduced the load of amyloid-beta plaques in the brains of an Alzheimer's disease mouse model while enhancing the animals' cognitive functions. More...
31 Jan 2013

Efficacy of Grape Seed Extract as an Anticancer Drug Improves as the Cancer Becomes More Aggressive

Cancer researchers have found that grape seed extract destroyed aggressive, metastasizing colorectal cancer cells more effectively than those at an earlier stage of growth did. More...
31 Jan 2013

Alternate Splicing Transforms Tumor Suppressor into Tumor Promoter

Short isoforms of the signaling molecule ribosomal S6 kinase 1, which are produced by the process of alternative RNA splicing, have been found to be tumorigenic and overexpressed in breast cancer cell lines and tumors. More...
31 Jan 2013
Image: A P. falciparum parasite exits a host erythrocyte loaded with the calcium concentration indicator. High fluorescence of the calcium indicator indicates increased calcium concentration within the host cell. The image is pseudocolored, tending from black (the lowest calcium concentration), through green and yellow to red (the highest calcium concentration) to indicate relative calcium concentration within the host cell. Increased calcium induces calpain activation at the time of parasite egress, as a consequence of upstream host cell signaling. The nuclei of daughter parasites are stained blue in a diagonal pattern from the upper right to the lower left as the parasites are actively exiting the cell. The host cell is no longer uniformly circular since it has been lysed. This shows a high concentration of calcium within the host cell at the end of the parasite cycle, when the host cell lyses and necessary for host calpain activation and break down of the host cytoskeleton (Photo courtesy of Doron Greenbaum, PhD, Perelman School of Medicine, University of Pennsylvania).

Investigational Drug Traps Parasites Inside Their Hosts' Cells

A recent paper described the molecular pathways utilized by intracellular parasites to survive in and escape from host cells and suggested that the investigational drug sotrastaurin may prove to effectively prevent infection by these pathogens. More...
30 Jan 2013
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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