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BioResearch

Image: Senior author Dr. Beverly M. Emerson (back right) and first author Dr. Fernando Lopez-Diaz (Photo courtesy if the Salk Institute for Biological Studies).

Mechanism Identified That Allows Cancer Cells to Survive Metabolic Stress and Chemotherapy

The ability of cancer cells to withstand both the metabolic stress of uncontrolled growth and that caused by chemotherapy depends on the action of transforming growth factor-beta, which prevents apoptosis by blocking p53 tumor suppressor signaling. More...
05 Jun 2013

Adipose-Derived Stem Cells Are More Potent Immunomodulators Than Those Derived from Bone Marrow

A recent paper revealed that stem cells derived from fat tissue were more potent than those originating from bone marrow as modulators of the body’s immune system. More...
04 Jun 2013

Enhanced Natural Killer Cell Activity Could Counter Influenza Virus Immune Response Evasion

Influenza viruses use their neuraminidase proteins to escape natural killer cell killing by impairing the NK cells' NKp46 surface receptor recognition of the viruses. More...
04 Jun 2013
Image: Contributing author Dr. Randolph Watnick (Photo courtesy of Harvard Medical School).

Nonmetastatic Tumors Release Proteins That Condition the Body Against Cancer Spread

Cancer researchers have found that certain cancers that do not metastasize, produce and secrete the protein thrombospondin-1 and, by doing so, condition distant organs to suppress metastasis. More...
04 Jun 2013
Image: Senior author Dr. Dwight A. Towler (Photo courtesy of Sanford-Burnham Medical Research Institute).

Imbalance in Molecular Signaling Pathways Leads to Arteriosclerosis

A paper described how an imbalance in expression of two genes contributes to development of cardiovascular disease by driving epithelial–mesenchymal transition in cells lining the arteries, which cause them to calcify and harden. More...
30 May 2013
Image: Senior author Dr. Ari Melnick (Photo courtesy of Weill Cornell Medical College).

Targeting EZH2 May Prevent Development of B-cell Lymphomas

A gene has been identified in immune system B-cell lymphocytes that when mutated fails to maintain the normal cell phenotype, which prompts the B-cells to enter a phase of uncontrolled cell division that results in the type of cancer known as B-cell lymphoma. More...
30 May 2013
Image: Senior author Dr. Daniel G. Anderson (Photo courtesy of Massachusetts Institute of Technology).

Biodegradable Nanoparticles Maintain Glucose Balance in Mouse Diabetes Model

Diabetes researchers have developed an acid-degradable polymeric "nanonetwork" made up of nanoparticles loaded with insulin that can detect elevated glucose levels in the blood of diabetics and then release the hormone. More...
30 May 2013
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.