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BioResearch

Image: Senior author Dr. Dongsheng Cai (Photo courtesy of Albert Einstein College of Medicine, Yeshiva University).

Molecular Signaling in the Hypothalamus Modulates the Aging Process

A recent paper linked the aging process to molecular signals produced in the hypothalamus, a small region of the brain that is responsible for maintaining normal function for numerous bodily processes, including blood pressure, body temperature, and glucose levels. More...
13 May 2013
Image: Researchers tracked down mutations in the phosphatase Wip1 in cancer cells that enhance the protein’s ability to shut down p53 and stymie the DNA damage repair process. The panel shows how cells respond to a dose of radiation that normally stops cells from dividing. The top row shows the cells one hour after the radiation, and the bottom row shows them 17 hours afterward. Cells with truncated Wip1 (left column) progress normally toward the point of cell division (orange nuclei), but most cells lacking truncated Wip1 (right column) fail to progress (red nuclei) (Photo courtesy of Dr. Indra Shaltiel, The Netherlands Cancer Institute).

Mutation That Blocks p53-Mediated DNA Repair Identified in Multiple Types of Cancer

A mutation in the protein phosphatase, Mg2+/Mn2+ dependent, 1D gene results in production of a C-terminally truncated form of the protein Wip1, which is a stable inhibitor of the p53 tumor suppressor. More...
13 May 2013
Image: Senior author Dr. Linda Resar (Photo courtesy of Johns Hopkins University).

Silencing the HMGA1 Gene Blocks Metastasis in Breast Cancer

Blocking the activity of the protein encoded by the HMGA1 gene in breast cancer cells renders them less aggressive and diminishes their ability to metastasize. More...
13 May 2013

Blocking Alzheimer’s Disease Process by Blocking Specific Protein

Scientists have discovered a potential approach for developing treatments to stop the disease process in Alzheimer’s disease by suppressing the activity of a little-known regulator protein called CD33. More...
13 May 2013
Image: When searching for a person, more areas of the brain are engaged (represented by the color green in the top image). The red color in the bottom image represents the brain’s attention shifting in a search for vehicles (Image courtesy of the University of California-Berkeley).

MR Shows How Brain Changes Focus to Track Objects

Based on new imaging findings, scientists have discovered that when humans initiate a targeted search, various visual and nonvisual areas of the brain unite to track down an object. More...
13 May 2013

Accelerated Genomics Cloud Promotion Designed to Enhance Research Workflows

Convey Computer reported that Nimbix has partnered with Convey to expand its Convey hybrid-core infrastructure, as part of The Accelerated Genomics Cloud (TAGC) promotion, which provides free runtime for qualified applicants. More...
13 May 2013
Image: Endocrine Tumor Syndrome. Inhibition of Hedgehog signaling in a MEN1 mouse model results in decreased islet cell proliferation. Immunofluorescence for BrdUrd and insulin in pancreas of Men1-excised mice fed with either vehicle control (left) or Erivedge/GDC-0449 (right) for four weeks at a dose of 100 mg/kg twice daily (Photo courtesy of Dr. Xianxin Hua, and Dr. Buddha Gurung, Perelman School of Medicine, University of Pennsylvania).

Failure of Mutant Menin Protein to Block Hedgehog Signaling Triggers a Type of Endocrine Cancer

Mutations in the gene that encodes the protein menin cause a hereditary cancer syndrome called MEN1 due to the inability of the mutant menin protein to block the oncogenic effects of enhanced Hedgehog signaling. More...
09 May 2013
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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