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BioResearch

Image: A functional magnetic resonance image (fMRI) showing brain areas more active in controls than in schizophrenia patients during a working memory task. Schizophrenia has been linked to decreased autophagy and enhanced cell death (Photo courtesy of Wikimedia Commons).

Schizophrenia Linked to Defects in the Brain's Autophagy Pathway

A recent paper has linked schizophrenia to inhibition of the cellular degradative process autophagy in the hippocampus segment of the brain.  More...
09 Jan 2014
Image: Trypanosoma cruzi in blood smear from patient with trypanosomiasis (Photo courtesy of the CDC – [US] Centers for Disease Control and Prevention).

Cruzipain Inhibitors Show Potential for Treatment of Chagas Disease

A new generation of antiparasitic drugs based on inhibitors of the enzyme cruzipain has been shown to have potential for more effective treatment of the chronic form of Chagas disease.  More...
08 Jan 2014

Diet Rich in Tomatoes May Lower Breast Cancer Risk

A diet rich in tomatoes may help protect at-risk postmenopausal women from breast cancer, according to new research. Moreover, fruits were found to raise levels of hormone involved in regulating blood sugar and fat.  More...
08 Jan 2014
Image: A case where a primary kidney tumor spread to an ovary: The vectors gathering in the metastatic tumor vessels glow green. The red staining shows the normal blood vessels of the ovary (Photo courtesy of Dr. David T. Curiel and Dr. Jeffrey M. Arbeit, Washington University School of Medicine).

Novel Adenoviral Vector Targets Tumor Blood Vessel Endothelial Cells

Researchers working with mouse cancer models used a novel gene-therapy approach to demonstrate the potential for directing therapeutic agents specifically to tumor blood vessels while avoid interaction with the liver or other normal tissues.  More...
07 Jan 2014

Mitochondrial Cause of Aging Can Be Reversed

Researchers have found a cause of aging in lab animals that can be reversed, possibly providing an avenue for new treatments for age-related diseases including type 2 diabetes, cancer, muscle wasting, and inflammatory diseases.   More...
07 Jan 2014
Image: A breast cancer cell in normal oxygen conditions (Photo courtesy of Dr. Daniele Gilkes, Johns Hopkins University).

Hypoxia-Inducible Factors Activate Breast Cancer Metastatic Genes

Factors related to hypoxia, the condition of low oxygen content that characterizes the microenvironment surrounding breast tumors, have been linked to the activation of genes that encode proteins that transform benign breast cancer cells into mobile and invasive metastatic cells.  More...
06 Jan 2014

Bacterial Persistence to Antibiotic Treatment Mediated by HipA Toxin Inhibition of Glutamyl-tRNA-Synthetase Activity

A team of molecular microbiologists has identified the molecular pathway that induces some types of "persistent" bacteria to enter a static or dormant phase when faced with antibiotic treatment.   More...
06 Jan 2014
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.