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BioResearch

Image: The structure of the ubiquitin-binding protein p62 (Photo courtesy of Wikimedia Commons).

Study Links p62 Protein to Likelihood of Liver Cancer Recurrence

Cancer researchers have linked levels of the ubiquitin-binding autophagy receptor protein p62 (Sequestosome-1) in liver cells to the development and recurrence of hepatocellular carcinomas (HCCs). More...
06 Jun 2016
Image: Electroporation jolts embryos with electricity to open holes that allow the CRISPR-Cas9 molecule (lower right) to enter and edit the DNA (Photo courtesy of Dr. Andrew Modzelewski, Dr. Lin He, University of California, Berkeley).

Rapid Injection Technique Improves Production of Genetically Engineered Mice

An electroporation method has been introduced that improves the production of genetically altered "knock-out" mice by requiring less time and being more efficient at introducing the CRISPR-Cas9 genome editing complex than is the current microinjection method. More...
06 Jun 2016
Image: An artist\'s rendition of the chromatin-nucleosome complex composed of DNA and histones. Polycomb-group proteins can remodel chromatin such that epigenetic silencing of genes takes place (Photo courtesy of Wikimedia Commons).

Mouse Model Advances Drug Development for Treating Lymphoma and Melanoma

Cancer researchers have established a mouse model system to study the involvement of EZH2 histone methyltransferase (EZH2) mutations in the development of lymphoma and melanoma tumors. More...
02 Jun 2016
Image: A three-dimensional rendering of a fluorescence image maps the piconewton forces applied by T-cells. The height and color indicates the magnitude of the applied force (Photo courtesy of Yang Liu, Emory University).

Nanoprobes Enable Measurement of T-Cell Binding Forces

A team of biochemical engineers has demonstrated that activation of immune system T-cells by foreign antigens has a physical component that is just as important to the process as immunochemical recognition. More...
02 Jun 2016
Image: Researchers have produced insulin-secreting cells from stem cells derived from the skin of patients with type I diabetes. The cells (blue), made from stem cells, can secrete insulin (green) in response to glucose (Photo courtesy of Millman Laboratory, Washington University School of Medicine).

Researchers Generate Stem Cell-derived Beta-cells from Patients with Diabetes

Diabetes researchers have succeeded in generating functional insulin-secreting beta cells from stem cells derived from patients with the type I form of the disease. More...
01 Jun 2016
Image: Cocoons of the silk moth Bombyx mori were used to isolate the silk fibroin used in the study (Photo courtesy of Wikimedia Commons).

Silk-Based Technique Stabilizes Fluid Samples for Diagnostics or Research

Drying blood or other biological fluid samples together with silk fibroin has been suggested as an alternative to refrigeration or drying on paper for transporting specimens from the field to the laboratory. More...
01 Jun 2016
Image: In some cancers, including chondroblastoma and a rare form of childhood sarcoma, a mutation in histone H3 reduces global levels of methylation (dark areas) in tumor cells but not in normal cells (arrowhead). This mutation arrests the cells in a proliferative state to promote tumor development (Photo courtesy of The Rockefeller University).

Histone Mutation Sufficient to Trigger Cancer Development

A missense mutation in a histone protein has been shown to be able to prompt the development of cancer cells without any change to the DNA of the cells that are involved. More...
01 Jun 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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