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BioResearch

Collaboration Designed to Accelerate Development of Personalized Cancer Therapeutics

Two European biotechnology companies are to collaborate on the development of cell and gene based treatment strategies in order to optimize the manufacture and delivery of personalized cancer therapeutics.   More...
27 Mar 2016
Image: Schematic of a Salipro nanoparticle. This technology may offer a wide range of potential applications, from structural biology to the discovery of new pharmacological agents (Photo courtesy of Jens Frauenfeld, Karolinska Institutet).

Nanotechnology Advance Enables High-Resolution Structural Studies of Membrane Proteins

A novel nanotechnology advance in the field of protein structural analysis allows for the isolation and reconstitution of membrane proteins in a lipid environment where they can by analyzed in their native state.  More...
23 Mar 2016
Image: Using the protein FimH (yellow/red) located at the tip of long protrusions, the bacterial pathogen E. coli (grey) attaches to cell surfaces of the urinary tract (Photo courtesy of Maximilian Sauer, ETH Zürich).

Structural Studies Reveal Molecular Basis for Bacterial Motility in the Urinary Tract

A team of molecular microbiologists has unraveled the mechanism used by Escherichia coli bacteria to bind to cells lining the urinary tract and explained how the pathogen migrates to the bladder despite the strong force of urine flowing in the other direction.   More...
23 Mar 2016
Image: NLXR1 C-terminal RNA binding domain (Photo courtesy of Wikimedia Commons).

Tumor Suppressor Gene Blocks Growth of Colon Cancer by Suppressing Key Tumor-Promoting Signaling Proteins

Cancer researchers have amassed a substantial body of evidence that points to the NLRX1 gene and its nlrx1 protein product as being powerful tumor suppressors that block the growth of colorectal cancer.  More...
22 Mar 2016
Image: Drug molecules (red) are embedded in a water-filled cavity inside of the phospholipid vesicle (Photo courtesy of the University of Basel/University of Fribourg).

Novel Class of Drug Delivery Liposomes Fail to Trigger an Adverse Immune Response

A novel class of liposomes prepared from the artificial phospholipid Pad-PC-Pad releases drugs at the site of arterial blockage, and has been shown to avoid activation of deleterious immune responses.  More...
22 Mar 2016
Image: A partially recellularized human whole-heart cardiac scaffold, reseeded with human cardiomyocytes derived from induced pluripotent stem cells, being cultured in a bioreactor that delivers a nutrient solution and replicates some of the environmental conditions around a living heart (Photo courtesy of Dr. Bernhard Jank, Ott Laboratory, Massachusetts General Hospital).

Stripped Heart Matrix Supports Growth of Rejection-Free Replacement Organ

A team of bioengineers used a decellularized heart matrix as scaffolding to rebuild the organ for transplantation without immune markers that would prime the organ for rejection.  More...
21 Mar 2016
Image: When seeded with heart cells, the flexible polymer scaffold contracts with a regular rhythm, just like real heart tissue (Photo courtesy of Boyang Zhang, University of Toronto).

Biomedical Engineers Reveal Organ-on-Chip Device for Drug Testing and Organ Repair

A soft, biodegradable polymer was used to form a three-dimensional organ-on-chip device for growth of artificial organs that could be used for drug testing or the repair or replacement of damaged organs.  More...
21 Mar 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.