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BioResearch

Image: The new active ingredient consists of DARPins (red and orange) that bend the HER2 receptors (blue) so no more growth signal is transmitted into the cell interior (below the cell membrane in yellow) (Photo courtesy of the University of Zurich).

Novel Class of Drugs Selectively Kills HER2-positive Breast Cancer Cells

A team of Swiss drug developers has designed a novel drug that cures breast cancer by completely blocking the activity of the surface receptor HER2 (human epidermal growth factor receptor 2). More...
16 Jun 2016
Image: SCA10 – An experimental drug has been designed to correct cell defects in diseases such as spinocerebellar ataxia type 10 (Photo courtesy of DTR).

Experimental Drug Targets Diseases Caused by Toxic RNA Nucleotide Repeats

A small molecule drug designed to interact with defective RNA was shown to displace sequestered proteins and correct defects in cells derived from patients suffering from the incurable neuromuscular disorder spinocerebellar ataxia type 10 (SCA10). More...
15 Jun 2016
Image: IFITM3 blocks Zika virus infection. When human cells are exposed to Zika virus they are overwhelming infected, as seen by the large number of green cells (left panel). When IFITM3 levels were boosted in these cells, the same amount of virus was prevented from replicating (right panel) (Photo courtesy of Brass Lab, University of Massachusetts Medical School).

Human Interferon-Induced Protein Blocks Zika Virus Infection

A team of molecular virologists has shown that the human protein IFITM3 (interferon-induced protein 3) inhibits Zika virus infection early in the viral life cycle and can prevent Zika-virus-induced cell death. More...
15 Jun 2016
Image: A pancreatic cancer cell. The nucleus is stained blue, while the fibers of the cytoskeleton are labelled with a red fluorescent dye (Photo courtesy of Dr. Nathalie Giese, Chirurgische Universitätsklinik Heidelberg, Germany).

Loss of MicroRNA Induces Pro-Metastatic Changes in Pancreatic Cancer Cells

Reduced activity of a specific microRNA (miRNA) is apparent in chronically inflamed pancreatic tissue and in early stages of pancreatic cancer (pancreatic ductal adenocarcinoma or PDAC) even before tumor formation. More...
14 Jun 2016
Image: A molecular model of the proteolytic enzyme neutrophil elastase (Photo courtesy of Wikimedia Commons).

Excess Elastase Prevents Muscle Regeneration in Duchenne Muscular Dystrophy

Overabundance of the enzyme neutrophil elastase has been linked to the progression of Duchenne muscular dystrophy (DMD) and the inability of patients afflicted with the disorder to repair damaged muscle. More...
14 Jun 2016
Image: Blocking expression of laminin (red) in pericyte and PIC stem cells in mice caused dramatic alteration to muscle fiber maturation (green), similar to that seen in muscular dystrophy patients (Photo courtesy of Rockefeller University).

Role of Laminin Defined in Muscular Dystrophy-Related Stem Cell Differentiation

The structural protein laminin has been found to play a critical role in determining whether a class of stem cells linked to the development of muscular dystrophy (MD) matures into muscle – which could prevent development of MD – or into fat – which would contribute to the development of MD. More...
13 Jun 2016
Image: ProAgio (green) binding to integrin v3 (Photo courtesy of Georgia State University).

Experimental Drug Stops Cancer Growth by Activating Integrin-Based Apoptosis

An experimental drug blocks tumor growth by binding to a novel site on the surface receptor integrin alphavbeta3, which activates the apoptotic factor caspase 8 and leads to the death of the cancer cells. More...
13 Jun 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.