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BioResearch

Image: Chromatin structure determines the function of the human genome. To visualize chromatin within intact cells, a method called ChromEM stains DNA and paints chromatin with a metal dust. The metal-coated chromatin is imaged by electron microscopy to generate a three-dimensional volume that reveals chromatin structure and organization. A single slice from the three-dimensional volume is shown here. Detailed chromatin structures are seen in a ChromEM stained cell (right panel, dark structures), but not in an unstained cell (left panel) (Photo courtesy of Dr. Clodagh O\'Shea, Salk Institute for Biological Studies and Dr. Mark Ellisman, University of California, San Diego).

Imaging Technique Reveals 3D Structure of DNA and Chromatin

Researchers have developed a method for visualizing the three-dimensional structure of chromatin, which explains how the two meter long molecular chain of genomic DNA fits inside the nuclei of human cells. More...
09 Aug 2017

Study Shows Curcumin Kills Childhood Neuroblastoma Cells

Treatment-resistant human childhood neuroblastoma tumor cells growing in culture were targeted and destroyed by the natural anti-cancer agent curcumin, which had been delivered to the cells via a novel class of cerium oxide nanoparticles. More...
08 Aug 2017
Image: Fundus photograph of a normal retina. New research suggests CRISPR/Cas gene editing could lead to novel therapies to prevent vision loss, blindness in those with diseases of the retina (Photo courtesy of the NIH).

Gene Editing Prevents Onset of Retinal Angiogenesis

Eye disease researchers demonstrated in a mouse model that delivery of the CRISPR/Cas9 gene editing tool via a viral vector could prevent the onset of angiogenesis, which causes vision loss and blindness and is a feature of several degenerative eye conditions including proliferative diabetic retinopathy (PDR), wet age-related macular degeneration (AMD), and retinopathy of prematurity (ROP). More...
07 Aug 2017

Study Highlights Ethnic Diversity of Lupus-Linked Genes

A large genotyping study has identified multiple regions of the genome linked to the autoimmune disease systemic lupus erythematosus (SLE) in individuals of European, African, and Hispanic Amerindian ancestry. More...
03 Aug 2017
Image: Biodegradable microneedle patch used to administer influenza booster immunization (Photo courtesy of Georgia State University).

Biodegradable Flu Booster Enhances Vaccine Effectiveness

A booster immunization administered via a novel biodegradable microneedle patch was found to significantly bolster the effectiveness of seasonal influenza vaccination, even providing some protection against of strains of the virus not included in the primary vaccine cocktail. More...
02 Aug 2017
Image: Microscopy images taken of Zika-infected primate placenta samples that were stained to detect Zika by immunohistochemistry. The left image shows a sample treated with the EASE protocol, with red/orange colored signals of Zika infection clearly visible (white arrows). The right image shows a sample treated with a standard protocol, and Zika virus - though present - was not detected (Photo courtesy of the University of Washington).

Horseradish Complex Increases Sensitivity of Immunochemical Assays

A new technique boosts the sensitivity of immunochemical reactions that rely on the enzyme horseradish peroxidase from 100 to 1,000 times. More...
01 Aug 2017
Image: CRISPR/Cas9 is a reprogrammable DNA cutting machine that is being used to edit genomes in many organisms for research purposes. A new resource provides a library of guide sequences that significantly increases CRISPR\'s specificity, while limiting off-target effects (Photo courtesy of Advanced Analytical Technologies).

RNA Library to Enhance CRISPR/Cas9 Gene Editing

A newly assembled library of RNA sequences was designed to maximize the usefulness of the CRISPR/Cas9 gene-editing tool. More...
31 Jul 2017
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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