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BioResearch

Image: The crystal structure of the Cas9 protein (Photo courtesy of Wikimedia Commons).

CRISPR/Cas9 Flexibility Slows Gene Editing Process

A team of Swedish molecular biologists has clarified the mechanism by which the CRISPR/Cas9 identifies and cleaves a specific DNA sequence among the many thousands that make up a cell's genome. More...
17 Oct 2017
Image: A digitally colorized transmission electron micrograph (TEM) of Zika (Photo courtesy of the CDC).

DNA-Based Vaccine Shown Safe and Effective

A team of vaccine developers used an advanced electroporation method to deliver and evaluate a new generation DNA-based vaccine designed to protect against Zika virus (ZIKV) infection. More...
16 Oct 2017
Image: An illustration of a TOP2 DNA-protein cross-link (TOP2cc in magenta) bound to DNA (Photo courtesy of Dr. Scott Williams).

Enzyme Mechanism Corrects Cellular DNA Damage

Researchers have identified a mechanism used by cells to correct damage to their DNA caused by chemotherapeutic drugs and some antibiotics. More...
16 Oct 2017
Image: A model of a potent peptide that targets influenza virus hemagglutinin and mimics the functionality of a broadly neutralizing antibody (Photo courtesy of Rameshwar U. Kadam, Ian Wilson\'s Laboratory, The Scripps Research Institute).

Potential Peptide Drugs Block Influenza Virus Activity

A recent paper described the design and structural characterization of a class of potent peptide inhibitors specifically targeted to block the activity of influenza virus hemagglutinin. More...
12 Oct 2017
Image: Ambrosia arborescens, the source of compounds toxic to cancer stem cells, is a medicinal plant with analgesic, anti-inflammatory, and antiseptic properties (Photo courtesy of Wikimedia Commons).

Anticancer Compounds Found in Medicinal Plant

Compounds isolated from the medicinal plant Ambrosia arborescens or derived from them synthetically were found to have potent toxic effect on cancer stem cells in three different breast cancer cell lines. More...
11 Oct 2017
Image: Mice infected with the bacteria Yersinia pseudotuberculosis form granulomas - structures that confine pathogens. But those with a mutant form of the RIPK1 enzyme, rendering cells unable to undergo a particular form of cell death called apoptosis, do not. This RIPK1-induced apoptosis is thought to be a strategy that helps dying cells alert their neighbors that an infection is present (Photo courtesy of the University of Pennsylvania).

Mechanism Identified Protects Cells from Virulence Factors

A team of molecular microbiologists has identified the mechanism that allows some cells to survive invasion by pathogenic bacteria such as species of Yersinia, which cause a range of illness from plague to gastrointestinal disease in humans. More...
10 Oct 2017
Image: The Crystallographic structure of NR0B1 (rainbow colored) complexed with the nuclear receptor protein LRH-1 (Liver receptor homolog-1) (Photo courtesy of Wikimedia Commons).

Advanced Proteomics Strategy Identifies Promising Drug Target

Use of an advanced proteomics strategy led to the discovery of a protein in non-small-cell lung cancer (NSCLC) cells that could be targeted by low molecular weight drugs. More...
09 Oct 2017
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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