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BioResearch

Image: A cryo-electron microscope. Cryo-EM provides near-atomic structural resolution without requirements for crystallization of the sample (Photo courtesy of Stanford University).

Structure of Calcium Channel Protein May Lead to New CF Drugs

Cryo-electron microscope (cryo-EM) molecular structure analysis studies have revealed the mechanism of action of the calcium-activated chloride channel protein TMEM16A. More...
26 Dec 2017
Image: Three T-cells surround a cancer cell. New drugs, such as immune checkpoint inhibitors, can help the immune system attack cancer, but the drugs’ effectiveness depends on the patient’s genetic makeup (Photo courtesy of the U.S. National Institutes of Health).

Immune Checkpoint Inhibitor Effectiveness Dependent on HLA Diversity

Findings reported in a recently published paper suggested that an individual’s own genes controlled his or her response to immunotherapy drugs known as immune checkpoint inhibitors. More...
25 Dec 2017
Image: An advanced in vivo Cas9-based epigenetic gene activation system enhances skeletal muscle mass (top) and fiber size growth (bottom) in a treated mouse (right) compared with an independent control (left). The fluorescent microscopy images at bottom show purple staining of the laminin glycoprotein in tibialis anterior muscle fibers (Photo courtesy of the Salk Institute for Biological Research).

Novel Gene Therapy Based on Modified Version of CRISPR/Cas9 Tool

A modified form of the CRISPR/Cas9 gene-editing tool does not cause "double-strand breaks" (DSBs) in the DNA, yet it retains the ability to target and activate specific sites in the genome. More...
21 Dec 2017

Transcriptomic Biomarker Assay Developed for Genetic Toxicology Testing

A new in vitro test was designed to solve the problem of false positive results that are frequently obtained when evaluating chemical compounds and potential drugs for their potential to cause genetic damage. More...
20 Dec 2017
Image: Manual isolation of a single live mitochondrion. The mitochondria can be seen under a microscope where a thin glass tube can be used to isolate a single mitochondrion from the dendrite region of the mouse neuron (Photo courtesy of Jacqueline Morris and Jaehee Lee, Perelman School of Medicine, University of Pennsylvania).

Increased Genome Variance Found in Mitochondria DNA Study

A team of molecular biologists has developed a method for identification of genetic variants present at the single-mitochondrion level in individual mouse and human neuronal cells, allowing for the extremely high-resolution study of mitochondrial mutation dynamics. More...
19 Dec 2017
Image: Clumps of toxic Alzheimer\'s A beta protein (white spots) are scarcer in the brains of mice treated with an antisense oligonucleotide that targets APOE4 (top) as compared with those given a placebo (bottom) (Photo courtesy of Tien-Phat Huynh, Washington University School of Medicine).

Oligonucleotide Treatment Reduces Neurological Damage in Alzheimer's Model

Neurological damage in mice that had been genetically engineered to express human apolipoprotein E4 (APOE4) - a gene linked to increased risk of developing Alzheimer's disease - was significantly reduced by treatment with an antisense oligonucleotide. More...
18 Dec 2017

AD Protective Gene Represents Promising Therapeutic Target

Alzheimer's disease (AD) researchers have identified a gene variant that is present in a small percentage of individuals with AD risk factors but who exhibit resilience by living well beyond 75 years of age without developing any clinical symptoms of cognitive decline. More...
14 Dec 2017
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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