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BioResearch

Image: Mouse (left) and human (right) alveolar progenitor cells grow into large lung organoids in culture, and make multiple types of epithelial cells including gas exchange type 1 cells (red) and surfactant-producing type 2 cells (green) (Photo courtesy of the Morrisey Laboratory, University of Pennsylvania).

Lung Progenitor Cells Enable Culture of 3D Organoids for Studies

An in vitro system for growth of three-dimensional lung organoids was used to characterize a line of alveolar stem cells that plays a critical role in repairing lung tissues damaged by severe influenza or other respiratory ailments such as chronic obstructive pulmonary disease (COPD). More...
15 Mar 2018
Image: The crystal Structure of K-Ras G12C (Photo courtesy of the Yale Cancer Center).

New Cancer Treatments Aimed at Preventing Drug Resistance

Cancer researchers have proposed a method for preventing development of resistance to chemotherapy that targets a mutation that appears spontaneously in certain lung tumors. More...
14 Mar 2018
Image: Left: Genetic differences are easily seen across individuals of different ancestries. Each point represents a person colored by his ancestry, and the graph is a reduction of the complex genetics vector of each person into two dimensions. Right: No differences are seen in the microbiome of individuals of different ancestries. Same as left, but the plot is of the microbiome reduced to two dimensions. Coloring is by ancestries and no separation can be seen (Photo courtesy of the Weizmann Institute of Science).

Environmental Influences Important in Determining Microbiome Composition

The contribution of an individual's genetic heritage is much less important than environmental factors in determining the makeup of his or her personal microbiome. More...
13 Mar 2018
Image: CRISPR/Cas9 is a reprogrammable DNA cutting machine that is being used to edit genomes in many organisms for research purposes (Photo courtesy of Advanced Analytical Technologies).

Naturally Occurring CRISPR/Cas9 Cuts DNA and RNA

A team of molecular microbiologists has identified a naturally occurring version of the CRISPR/Cas9 gene-editing complex that cuts both DNA and RNA with equal proficiency. More...
12 Mar 2018
Image: Atomic force microscopy image of exosomes (white ball-like structures) and exomeres (purple and yellow) secreted by melanoma tumor cells (Photo courtesy of Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center).

Cancer Progression Linked to Activity of Exosomes and Exomeres

The separation technique asymmetric flow field-flow fractionation was used to identify and characterize two distinct exosome subpopulations, and the method enabled discovery of an abundant population of non-membranous nanoparticles termed "exomeres." More...
08 Mar 2018
Image: The 123B9 dimeric peptide (right panel) has a scorpion-like shape with two arms that bind to EphA2-expressing cancer cells and a tail (brown) comprising the cytotoxic chemotherapeutic agent paclitaxel. The compound recognizes the surface of cancer cells that are rich in EphA2 (labeled in red in the left panel) and deliver the cytotoxic agent (Photo courtesy of the Pellecchia Laboratory, University of California, Riverside).

Oncogene Used as Drug Transporter to Block Tumor Growth

A potent peptide-drug conjugate that targets the EphA2 oncogene was shown to reduce circulating cancer cells and metastases in breast cancer models. More...
07 Mar 2018
Image: When injected into tumors, this therapy forms a gel to attack cancer cells (Photo courtesy of the Gu Laboratory, University of North Carolina).

Novel Hydrogel Slows Tumor Growth and Prevents Recurrence

A team of cancer researchers developed a novel hydrogel device designed to be injected at the site of a tumor, where it forms a scaffold for sequential release of chemotherapeutic and immunotherapeutic drugs. More...
06 Mar 2018
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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