某些类型肺癌可见致癌基因融合
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By LabMedica International staff writers Posted on 26 Nov 2013 |
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肺腺癌（非小细胞肺癌的一种形式）的某些子集由产生致癌的“融合基因”的突变所引发。
美国达纳-法伯癌症研究所 (Boston, MA, USA）和科罗拉多大学癌症中心 (Denver, USA）的研究者们对 36 名肺腺癌患者的肿瘤样品进行了下一代 DNA 测序，这些肿瘤患者没有任何已知的致癌基因突变。研究者发现，取自两位不吸烟女性患者样品的 NTRK1（神经营养性酪氨酸激酶受体 1 型）区域已融合为常见的远端基因（1 位患者发生于 MPRIP 基因，1 位患者发生于 CD74 基因）。
结果发表于 2013 年 10 月 27 日网络版的 《Nature Medicine》 杂志，揭示三份样品 (3.3%) 显示出 NTRK1 基因融合证据。
“这些结果提示，少数百分比的肺腺癌患者——此前没能发现癌细胞基因异常的人群——肿瘤生长受涉及 NTRK1 融合的驱动，”特约作者，达纳-法伯癌症研究所医学副教授 Pasi A. Jänne 博士声称。“由于肺癌是一种常见的癌症，即使是百分之几的比率也具有显著的意义，经换算可成为大量的患者数量。我们的研究结果表明，针对此子集的肺癌患者进行靶向治疗可能有效。”
Related Links:
达纳-法伯癌症研究所
科罗拉多大学癌症中心
美国达纳-法伯癌症研究所 (Boston, MA, USA）和科罗拉多大学癌症中心 (Denver, USA）的研究者们对 36 名肺腺癌患者的肿瘤样品进行了下一代 DNA 测序，这些肿瘤患者没有任何已知的致癌基因突变。研究者发现，取自两位不吸烟女性患者样品的 NTRK1（神经营养性酪氨酸激酶受体 1 型）区域已融合为常见的远端基因（1 位患者发生于 MPRIP 基因，1 位患者发生于 CD74 基因）。
结果发表于 2013 年 10 月 27 日网络版的 《Nature Medicine》 杂志，揭示三份样品 (3.3%) 显示出 NTRK1 基因融合证据。
“这些结果提示，少数百分比的肺腺癌患者——此前没能发现癌细胞基因异常的人群——肿瘤生长受涉及 NTRK1 融合的驱动，”特约作者，达纳-法伯癌症研究所医学副教授 Pasi A. Jänne 博士声称。“由于肺癌是一种常见的癌症，即使是百分之几的比率也具有显著的意义，经换算可成为大量的患者数量。我们的研究结果表明，针对此子集的肺癌患者进行靶向治疗可能有效。”
Related Links:
达纳-法伯癌症研究所
科罗拉多大学癌症中心
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