Universal HPLC Detector Offers Near Nanogram Sensitivity

An ultra-sensitive, universal nano-quantity analyte detector (NQAD) presents a major advancement in high-performance liquid chromatography (HPLC) detection capability.

The NQAD nano-quantity analyte detector is a new and completely different kind of aerosol-based detector for HPLC. Based on condensation nucleation (CNLSD) technology, the NQAD offers the ability to detect sub-nanogram levels. Benefiting from ultra-high sensitivity, the detector is suitable for searching for drug impurities, degradation products, excipients, and when industrial hygiene is a concern. Both previously easy and hard-to-measure compounds can be quantified accurately with minimal sample preparation.

The NQAD detector also offers a wide dynamic range with superior linearity when compared to other aerosol-based detectors. The detection of the NQAD detector is near universal for compounds that are less volatile than the mobile phase. Chromophores and fluorophores are not needed for detection, thereby eliminating or decreasing the need for compound derivatization. The detector is optimized for use in ultra high performance liquid chromatography (UHPLC), HPLC, and supercritical-fluid chromatography (SFC). Easy to install and operate, with one of the smallest footprints available the NQAD is suitable for use in any laboratory.

The detector was developed by Dorton Analytical (Thames, Oxfordshire, UK).

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Available from Dorton Analytical