Labeled Complementary Nucleic Acid Strand Localizes Tissue Section Sequences

Rapid in situ hybridization (ISH) was successfully demonstrated on a new wave reactant-product decoupling (RPD) system.

ISH uses a labeled complementary DNA or RNA strand to localize a specific sequence in a section of tissue. This is distinct from immunohistochemistry, which localizes proteins in tissue sections.

The wave system is a rapid IHC System designed to enhance capabilities of the anatomic pathology laboratory, provide clinicians with rapid, reliable, actionable diagnostic information, and advance patient care.

In 2008, Celerus Diagnostics (Carpinteria, CA, USA) introduced rapid IHC with its wave system, a semiautomated platform that delivers high-quality IHC results in 15 minutes. The addition of on-board pretreatment steps to the existing 15-minute staining protocols, results in totally automated IHC in one hour, compared to industry standards of two-and-a-half-four hours.

Celerus Diagnostics will launch the wave RPD system, a totally automated immunohistochemistry (IHC) and in situ-hybridization (ISH) staining system to the market this year. It will be introduced at the United States and Canadian Association of Pathologists (USCAP) annual meeting to be held in Washington DC, (USA) on March 22-24, 2010.

"We've had success with both fluorescent and chromogenic markers," said Jason Lusk, vice president of business development at Celerus. "This is significant because the importance of molecular targets as companion diagnostics to identify patients for drug therapies continues to grow."

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Celerus Diagnostics