First Saliva Diagnostic Test for Endometriosis Delivers Reliable Results Within Days

Endometriosis affects approximately 1 in 10 women globally, with a range of symptoms that can severely impact their health, quality of life, and fertility. The delay in diagnosis, which can take between 7 to 10 years, is a significant barrier to improving care, life quality, and fertility outcomes. Now, a pioneering saliva-based diagnostic test for endometriosis offers new possibilities for early and non-invasive diagnosis of this painful disease.

The Ziwig Endotest, developed by Ziwig (Lyon, France), is a saliva test for endometriosis that provides a reliable diagnosis within just a few days. Ziwig is transforming the diagnosis and treatment of women's health conditions by harnessing the power of salivary RNA. The Ziwig Endotest is the first-ever application of salivary microRNA1-6 in gynecology. This test requires only a simple saliva sample, with the diagnosis performed in the laboratory. It is based on high-throughput sequencing of the microRNA found in saliva, combined with artificial intelligence (AI) to process the large volumes of data generated. Using the Ziwig Endotest, a diagnosis can be made in just a few days with exceptional accuracy (97.4% sensitivity, 93.7% specificity). The test enables clinicians to reliably confirm or exclude a diagnosis of endometriosis and distinguish it from other conditions with similar symptoms. It is particularly useful in complex cases where medical imaging may be inconclusive.

Image: The saliva test for endometriosis provides a reliable diagnosis within just a few days (Photo courtesy of Ziwig)

Ziwig’s non-invasive approach to saliva sampling, along with technological advancements in sequencing and AI, makes accurate, early diagnosis of endometriosis more accessible. The company’s focus on the RNA and extracellular vesicles in saliva represents a milestone in personalized medicine. The Ziwig Endotest offers a breakthrough biological test for healthcare providers and patients by reducing diagnostic delays, identifying complex and early-stage cases sooner, providing an alternative to invasive procedures, and enhancing fertility preservation through earlier diagnosis.

"With Ziwig Endotest we are determined to end the unacceptable diagnostic wandering that leaves many women in pain,” said Yahya El Mir, Ziwig CEO-Founder.

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