Blood Test to Detect Protein Biomarkers Identified Using Breast Milk Could Enable Breast Cancer Screening

A simple blood test for women of all ages and risk levels could one day be possible thanks to a new set of protein biomarkers identified by researchers using breast milk.

The newly identified biomarkers are for a specific type of cancer called invasive ductal carcinoma (IDC), one of the most common types of breast cancers. However, the researchers at Clarkson University (Potsdam, NY, USA) who identified the biomarkers say that their approach could be used to identify biomarkers for other types of breast cancer. For the study, breast milk samples were obtained from three women diagnosed with breast cancer and three women without cancer. Using liquid chromatography with tandem mass spectrometry, the researchers compared the relative levels of certain proteins between the two groups to identify differences in the women with cancer. The analysis revealed 23 proteins that were dysregulated. All the proteins that showed differences were previously shown to play a role in cancer or tumor development.

Now that the researchers have identified a biomarker set, they plan to confirm it with a larger group of women. Then, they will test the protein biomarkers’ applicability in blood serum. If those tests are successful, a blood test could be developed to be used on women of any age to monitor protein changes for detection of breast cancer.

“Although mammograms are a useful tool for catching breast cancer early, they aren’t typically recommended for low-risk women under 40,” said Danielle Whitham, a doctoral candidate at Clarkson University. “Because the biomarkers we found in breast milk are also detectable in blood serum, screening could potentially be done in women of any age using blood or breast milk.”

“If our future studies are successful, it could change how women are monitored for breast cancer and aid in earlier diagnosis,” added Whitham. “This could even lead to a higher survival rate in women. We used breast milk because it contains proteins, epithelial cells and immune cells, all of which provide a great deal of information about what is happening in a woman’s body during a crucial time in breast development.”

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Clarkson University