MicroRNA Technology Agreement Helps in Pancreatic Cancer Detection

A new research agreement could lead to ways of detecting cancer before it spreads.

The Translational Genomics Research Institute's (Tgen; Phoenix, AZ, USA) Dr. Glen Weiss, an associate investigator in Tgen's cancer and cell biology division, plans initially to work with Asuragen, Inc. (Austin, TX, USA) to search for new ways of screening patients for pancreatic cancer, one of the fastest moving and lethal types of cancer.

The project will combine the microRNA expertise and diagnostic development experience of Asuragen with Tgen's strengths in basic and clinical research. TGen moved to collaborate with Asuragen on this project because of its reputation as an excellent assay development partner, demonstrated market success and research compatibility with Dr. Weiss' work with microRNA technology.

Currently, there is no screening test in routine use for pancreatic cancer, which in the United States is the fourth leading cause of cancer death, annually killing more than 35,000. Moreover, there is no diagnostic test, other than examining diseased tissue. As a result, pancreatic cancer frequently is not detected until the cancer is in advanced stages, when patients face diminishing treatment options.

TGen Clinical Research Services at Scottsdale Healthcare (TCRS) is a partnership between TGen and Scottsdale Healthcare that enables laboratory discoveries to be quickly turned into targeted therapies that can be tested with patients at the Virginia G. Piper Cancer Center in Scottsdale (AZ). "If you can use a blood test to identify metastatic pancreatic cancer before it shows up on imaging tests, we may prevent unnecessary surgery or invasive procedures,” said Dr. Weiss who also is director of thoracic oncology at TCRS. "In addition, our collaboration will seek to identify better prognostic indicators for predicting the course of the disease and the prospects for recovery.”

Asuragen is a leader in the development and use of microRNA technology to help find biomarkers that can pinpoint the genetic origins of disease. MicroRNAs are small molecules that regulate gene expression in the process of making proteins as well as directing the structure and function of cells. This regulation typically prevents cancer and other diseases.

Asuragen's focus on diagnostics for pancreatic cancer includes the development of its pancreatic adenocarcinoma test, which was the world's first microRNA-based diagnostic test. This Clinical Laboratory Improvement Amendments (CLIA)-based test is intended as an aid-in-diagnosis of pancreatic ductal adenocarcinoma (PDAC) versus chronic pancreatitis in resected pancreatic specimens. Asuragen is currently conducting a multiinstitution study to develop a miRNA-based test for PDAC using fine needle aspirate specimens.

"This project to develop a blood-based, miRNA test for pancreatic cancer is a natural extension of Asuragen's pancreatic cancer projects and represents an exciting step forward in the effort to improve diagnosis and treatment of this deadly form of cancer,” said Matt Winkler, CEO and CSO of Asuragen. "Asuragen recognized the value of blood-based miRNA markers very early and has been working steadily to enable early detection of cancer in circulating biofluids using miRNAs. We see great potential for this to transform screening and diagnosis of pancreatic cancer and ultimately the survival of pancreatic cancer patients.”

The only current prognostic in pancreatic cancer is a blood test for tumor markers known as CA [cancer antigen]-19-9. "If we can identify biomarkers that improve on the performance of CA-19-9 as a prognostic test for disease relapse after surgery, that may be helpful in identifying those higher-risk individuals for new therapies that may prevent disease relapse,” Dr. Weiss said.

TGen and Asuragen will work with blood samples collected from healthy individuals, those with pancreas abnormalities, and pancreatic cancer from collections developed through Tgen's Pancreatic Cancer Biospecimens Repository, which is directed by Dr. Michael Demeure, a TGen senior investigator and endocrine surgeon. Other pancreatic cancer samples will come from a collection developed by the Pancreatic Cancer Research Team (PCRT), an international collaboration of pancreatic cancer investigators led, in part, by TGen.

"We are excited that our collection might help lead to earlier detection of pancreatic cancer and may lead to new prognostic biomarkers for this disease,” said Dr. Demeure.

Related Links:
Translational Genomics Research Institute
Asuragen