Colorectal Cancer Screening Test Is Simple and Convenient

A noninvasive, safe, simple, and convenient screening test for colorectal cancer uses only a single stool sample.

Called ColoSure, the assay assesses the presence of active colorectal cancer in average-risk individuals. The assay is performed, after a simple collection process, on a complete bowel movement, and it examines DNA in exfoliated colon cells for a change that can indicate the presence of cancer. The ColoSure assay can be used as a part of a comprehensive, ongoing colorectal cancer-screening program, and is complementary to both traditional and virtual colonoscopies. ColoSure has a sensitivity range of 72-77%, and a specificity range of 83-94%

The clinical test looks for a DNA change in the vimentin gene, which is important to immunity and other important cell processes in the body. If the vimentin gene is hyper-methylated, or "turned off,” this could indicate colon cancer. A study, published in the September 2008 issue of the American Journal of Gastroenterology, showed that detecting methylated vimentin DNA in feces was both highly sensitive and highly specific for detecting early-stage, curable colon cancers.

DNA Direct (San Francisco, CA, USA) announced that the ColoSure screening test is now available and can be ordered through the company's website. DNA Direct's personalized, web-enabled report for recipients of the ColoSure test includes an overview of test results, a lab report, a letter to bring to their physician, and recommended follow-up.

Reports also reinforce awareness of the signs and symptoms of colorectal cancer, and include an option to schedule a reminder for the patient's next screening. Finally, the report includes a section on how ColoSure works, ways to change contributing lifestyle factors, a list of resources for patients and important facts about colorectal cancer.

At least 60% of Americans age 50 and older have never been screened for colorectal cancer, even though the American Cancer Society recommends a lifelong screening program for those aged 50 or older, including a colonoscopy every 10 years. Each year, nearly 150,000 new cases are diagnosed, and up to 50,000 people die of colorectal cancer. If caught early, the survival rate is close to 95%--but 50% of patients with colorectal cancer are diagnosed with advanced disease, which is less likely to be surgically curable.

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DNA Direct