We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

LabMedica

Download Mobile App
Recent News Expo Clinical Chem. Molecular Diagnostics Hematology Immunology Microbiology Pathology Technology Industry Focus

Easy-To-Use Point-Of-Care Testing Device Accurately Measures Cortisol Levels in Blood

By LabMedica International staff writers
Posted on 04 Sep 2024

Stress manifests in various forms, and the inability to manage high stress levels can lead to severe health problems like depression and Alzheimer's disease. The development of a cost-effective, reproducible, and easy-to-use point-of-care testing device that accurately measures cortisol—a key stress biomarker in the blood—has been a significant goal of researchers. Such a device could greatly facilitate the quick diagnosis of elevated cortisol levels, thereby significantly enhancing quality of life. However, the electrodes used in currently available devices are not stable under varying conditions such as changes in pH and temperature, resulting in a limited shelf life and difficulties in commercial production.

Now, researchers at Xi'an Jiaotong-Liverpool University (XJTLU, Suzhou, China) have developed an innovative cortisol detector that addresses these challenges. Traditional cortisol sensors use reference electrodes with a silver layer that tends to oxidize and destabilize during electrochemical measurements. In the new study published in the journal Talanta, the researchers introduced iridium oxide nanoparticles to coat the silver layer, significantly enhancing the stability, sensitivity, and reproducibility of cortisol measurements in point-of-care settings. This is the first application of iridium oxide in this manner. The resulting device is simple and affordable, capable of detecting cortisol levels at concentrations 3,000 times lower than the typical cortisol range found in blood, making it highly suitable for commercial use. Additionally, the iridium oxide-modified electrodes have increased the selectivity of the tests, improving the device’s overall efficacy.


Image: A new and improved detector can accurately measure levels of cortisol – a stress biomarker in the blood (Photo courtesy of XJTLU/https://doi.org/10.1016/j.talanta.2024.126776)
Image: A new and improved detector can accurately measure levels of cortisol – a stress biomarker in the blood (Photo courtesy of XJTLU/https://doi.org/10.1016/j.talanta.2024.126776)

"One problem with the current solutions is that there is much similarity between cortisol and other hormones such as progesterone, testosterone, and corticosterone. This means it is difficult for the detectors to tell them apart,” said Dr. Graham Dawson, XJTLU Associate Professor and co-author. “Our iridium oxide-modified electrode is selective enough to distinguish the different hormones and helps to solve this issue."

Related Links:
XJTLU


New
Gold Member
ANCA IFA
Kallestad Autoimmune ANCA IFA Complete Kit
Antipsychotic TDM Assays
Saladax Antipsychotic Assays
New
H.pylori DNA Extraction Kit
Savvygen Stool NA Extraction Kit
New
Four-in-One Desktop Testing Solution
GULP-1sim/GULP-1ble

Latest Molecular Diagnostics News

MicroRNA-Based Test Identifies 12 Cancers Simultaneously Across Any Stage

New Blood Test Platform Simultaneously Measures Over 100 Biomarkers of Alzheimer's Disease

First-Ever Blood Test Diagnoses Maternal Autoantibody Related Autism