Using Nucleic Acids From Urine for Diagnostics

A new method for the isolation of cell-free nucleic acids from urine is simple, cost-effective, applicable to small and large volumes of urine, and can be used for transrenal (Tr)-DNA preservation, storage, purification, and diagnostic tests.

The new method for the isolation of low-molecular-weight cell-free Tr-DNA from urine was developed by Xenomics (New York, NY, USA). Using this new approach, Xenomics is planning to develop kits to accelerate the application of its Tr-DNA technology in different areas of DNA-based molecular diagnostics, in both humans as well as animals. Similar products will be developed for clinical diagnostic tests, based on an analysis of Tr-DNA.

"This new method of DNA isolation from urine specimens is an important milestone for Xenomics,” commented Dr. L. David Tomei, CEO and co-founder of Xenomics. "Many of the available DNA isolation kits were designed for purification of large genomic DNA in blood or tissue specimens. The new techniques are specifically designed to isolate Tr-DNA from simple urine specimens, and used to detect the genetic signature of a broad variety of diseases in the body.”

Obtaining urine is simple and does not involve invasive procedures. In addition, it can be sampled easily in both children and adults. Small DNA markers in urine specimens can come from throughout the body and are clearly distinct from the body's genetic makeup. Xenomics aims to apply its Tr-DNA test platform to develop highly sensitive, truly non-invasive molecular diagnostics, which will replace outdated blood, sputum, and tissue testing technologies, many of which are not sufficiently sensitive or specific and are often hazardous and difficult to automate.



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