Leica Biosystems and Bio-Techne Expand Spatial Multiomic Collaboration

Bio-Techne Corporation (Minneapolis, MN, USA) has expanded the longstanding partnership between its spatial biology brand, Advanced Cell Diagnostics (ACD, Newark, CA, USA), and Leica Biosystems (Nussloch, Germany), a global leader in anatomic pathology solutions. This expansion builds on the strong partnership between Bio-Techne and Leica Biosystems, established in 2015, to deliver automated in-situ hybridization (ISH) workflows that streamline spatial biology research. The expanded spatial multiomic collaboration now includes automation of ACD's new RNAscope Multiomic LS Assay and protease-free workflows on Leica's BOND RX research staining instrument, further advancing the capabilities of spatial biology research.

The RNAscope Multiomic LS Assay enables simultaneous fluorescent detection of up to six RNA and/or protein biomarkers on the same slide, preserving RNA and protein integrity while maintaining tissue morphology. Additionally, ACD introduced a protease-free workflow for RNAscope 2.5 single-plex assays on the Leica BOND RX staining instrument, further advancing multiomic visualization from discovery research to translational applications. The RNAscope in situ spatial assays have been widely adopted by top academic institutions, pharmaceutical companies, and service providers worldwide, contributing to over 12,000 peer-reviewed publications.

Image: Tumor-associated macrophages visualized using the Multiomic LS Assay (Photo courtesy of ACD)

"The automation of Bio-Techne's innovative RNAscope protease-free assays on the Leica BOND RX platform marks a significant milestone in spatial multiomics research," said Dr. Matt McManus, President of Bio-Techne's Diagnostics & Spatial Biology Segment. "High-precision visualization of RNA and protein biomarkers on the same slide empowers researchers with a streamlined, fully automated solution that preserves sample integrity and accelerates scientific discoveries in translational and clinical research."

"At Leica Biosystems, we are committed to empowering researchers with innovative automation solutions that accelerate spatial biology discovery," said Karan Arora, Senior Vice President of Advanced Assays at Leica Biosystems. "The integration of ACD's RNAscope Multiomic LS Assay on the BOND RX reinforces our mission to provide cutting-edge tools that enhance precision and scalability in life science research."

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