We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

LabMedica

Download Mobile App
Recent News Expo Clinical Chem. Molecular Diagnostics Hematology Immunology Microbiology Pathology Technology Industry Focus

Hematological Parameters Compared in Psoriasis Patients

By LabMedica International staff writers
Posted on 19 Oct 2021
Psoriasis is a chronic, immune-mediated disorder that can involve the skin and/or joints. Four clinical types of psoriasis are currently recognized: psoriasis vulgaris (PsV), pustular psoriasis (PP), erythrodermic psoriasis (PsE), and arthritic psoriasis (PsA).

Systemic inflammation plays an important role in the pathogenesis of psoriasis, and numerous inflammatory mediators have been implicated, including interleukins (e.g., IL-17, IL-1β), other cytokines and chemokines, and serum autoantibodies. However, there is an urgent need to identify better markers for the diagnosis and assessment of clinical severity and outcomes of psoriasis.

Image: Psoriatic plaques, showing a silvery center surrounded by a reddened border (Photo courtesy of Jane Bianchi, BA)
Image: Psoriatic plaques, showing a silvery center surrounded by a reddened border (Photo courtesy of Jane Bianchi, BA)

Dermatologists at the Peking Union Medical College (Beijing, China) carried out hospital-based cross-sectional retrospective study that included a total of 477 patients (328 males, 149 females; mean age 43.5 ± 14.3 years): 347 with psoriasis vulgaris (PsV), 37 with generalized pustular psoriasis (GPP), 45 with erythrodermic psoriasis (PsE), 25 with arthritic psoriasis (PsA) and 23 with mixed psoriasis, and 954 healthy control subjects (656 males, 298 females; mean age 43.5 ± 14.3 years).

Demographic, clinical, and laboratory data were obtained from electronic or handwritten medical records. The following parameters were extracted: white blood cell (WBC), neutrophil, lymphocyte, red blood cell (RBC), and platelet counts, and hemoglobin (Hb) levels. In addition, neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were calculated and the psoriasis area severity index (PASI) scoring system was used to assess the severity of PsV.

The investigators reported that compared with the healthy control group, patients with psoriasis had higher total white blood cell (WBC), neutrophil, platelet counts, neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR), but lower hemoglobin (Hb) levels, lymphocyte and red blood cell (RBC) counts. NLR values in the PsV group were significantly lower than those in the GPP, PsE, and PsA groups, with GPP group being the highest. PLR values in the PsV group were significantly lower than those in the GPP, PsE, and PsA groups. There was no significant correlation between the psoriasis area severity index (PASI) score and either the NLR or PLR in the PsV group.

The authors concluded that their results highlight the significant differences in NLR and PLR among psoriasis patients. Neutrophil counts and NLR were significantly higher in psoriasis group compared with the control group, with the GPP group having the highest NLR. In addition, platelet counts and PLR are increased in psoriasis patients, especially in the most severe subtype. The study was published on September 26, 2021 in the journal BMC Immunology.

Related Links:
Peking Union Medical College


Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Specimen Collection & Transport
POCT Fluorescent Immunoassay Analyzer
FIA Go
New
Gold Member
Systemic Autoimmune Testing Assay
BioPlex 2200 ANA Screen with MDSS

Latest Hematology News

POC Finger-Prick Blood Test Determines Risk of Neutropenic Sepsis in Patients Undergoing Chemotherapy

First Affordable and Rapid Test for Beta Thalassemia Demonstrates 99% Diagnostic Accuracy

Handheld White Blood Cell Tracker to Enable Rapid Testing For Infections