We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

LabMedica

Download Mobile App
Recent News Expo Clinical Chem. Molecular Diagnostics Hematology Immunology Microbiology Pathology Technology Industry Focus

Blood Test Can Rule Out Preeclampsia in Pregnant Women

By LabMedica International staff writers
Posted on 26 Jan 2016
A clinical study has shown that a new preeclampsia test can better predict which women will, and will not, develop preeclampsia and this could reduce hospitalization by up to 50%, saving healthcare systems excess expenditure.

Preeclampsia is difficult to diagnose and manage and physicians estimate that around 80% of pregnant women suspected of having preeclampsia do not go on to develop it. Many of those women are unnecessarily hospitalized while other preeclamptic patients are only detected at a very late stage, endangering both them and their babies.

Image: Soluble Flt-1 (sFlt-1) causes endothelial dysfunction by antagonizing vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) (Photo courtesy of the International Society of Nephrology).
Image: Soluble Flt-1 (sFlt-1) causes endothelial dysfunction by antagonizing vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) (Photo courtesy of the International Society of Nephrology).

An international team of scientists led by those at the Campus Virchow–Klinikum Charité (Berlin, Germany) performed a prospective, multicenter, observational study to derive and validate a ratio of serum soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) that would be predictive of the absence or presence of preeclampsia in the short term in women with singleton pregnancies in whom preeclampsia was suspected (24 weeks to almost 37 weeks of gestation).

The study was designed to derive and validate a cutoff point of the sFlt-1: PlGF ratio for the prediction of the short-term absence or presence of preeclampsia, in a two-phase approach (development and validation). In the development phase, the scientists used data from 500 participants to derive the sFlt-1: PlGF ratio cutoff point for the prediction model, which was validated with the use of data from 550 additional participants. Maternal serum levels of sFlt-1 and PlGF, measured in pg/mL were determined by means of the fully automated Elecsys assays for sFlt-1 and PlGF on an electrochemiluminescence immunoassay platform (cobas e analyzers, Roche Diagnostics, Basel, Switzerland) and were used to calculate the sFlt-1:PlGF ratio.

In the development cohort (500 women), the teams identified a sFlt-1: PlGF ratio cutoff of 38 as having important predictive value. In a subsequent validation study among an additional 550 women, a sFlt-1: PlGF ratio of 38 or lower had a negative predictive value (i.e., no preeclampsia in the subsequent week) of 99.3%, with 80.0% sensitivity and 78.3% specificity. The positive predictive value of a sFlt-1: PlGF ratio above 38 for a diagnosis of preeclampsia within four weeks was 36.7% with 66.2% sensitivity and 83.1% specificity.

The authors concluded that a sFlt-1: PlGF ratio of 38 or lower can be used to predict the short-term absence of preeclampsia in women in whom the syndrome is suspected clinically. Manu Vatish, MB, ChB, DPhil, a Consultant Obstetrician and coauthor of the study, said, “A preeclampsia diagnosis can be extremely frightening for women and their families. The condition can be life-threatening and affects around 5% of all pregnancies. Preeclampsia symptoms are often nonspecific and, without a reliable test to diagnose the condition, many women are admitted to hospital unnecessarily.” The study was published on January 7, 2016, in the New England Journal of Medicine (NEJM).

Related Links:

Campus Virchow–Klinikum Charité
Roche Diagnostics



Gold Member
Chagas Disease Test
CHAGAS Cassette
Verification Panels for Assay Development & QC
Seroconversion Panels
New
Mycoplasma Pneumoniae Virus Test
Mycoplasma Pneumoniae Virus Detection Kit
New
Lyme Disease Test
Lyme IgG/IgM Rapid Test Cassette

Latest Clinical Chem. News

Carbon Nanotubes Help Build Highly Accurate Sensors for Continuous Health Monitoring

Paper-Based Device Boosts HIV Test Accuracy from Dried Blood Samples

AI-Powered Raman Spectroscopy Method Enables Rapid Drug Detection in Blood



Sekisui Diagnostics UK Ltd.