Innovative Analyzer Helps Control Propofol Levels

A novel propofol-measurement system determines intravenous (IV) concentrations of the induction anesthetic in whole blood samples.

The Pelorus 1000 Propofol Analyzer is a benchtop device that works by titrating propofol to whole blood concentration, and is expected to be a key tool in individualizing and optimizing therapy at the patient level, both in the operating room (OR) and the intensive care unit (ICU). The device is easy to operate via a simple start-up and shut-down procedure accessed via a dedicated touch-screen computer panel, with a single-use cartridge for each individual measurement. No sample preparation required, and quality control (QC) is provided at three concentration levels. A simple daily calibration routine ensures consistent, accurate, and reliable results in a fast five-minute analysis time. The Pelorus 1000 Propofol Analyzer is a product of Sphere Medical (Cambridge, United Kingdom), and has received the European Community (CE) marking of approval.


"I am extremely pleased that Sphere has been able to bring this innovation to the market following successful clinical trials earlier this year,” said Stuart Hendry, CEO of Sphere Medical. "We are already working with leaders in the critical care field, and I look forward with anticipation to the studies being performed that will begin prove the clinical and economic benefits of real time measurement of propofol concentration.”

Propofol is a short-acting, intravenously administered hypnotic agent. Its uses include the induction and maintenance of general anesthesia (GA), sedation for mechanically ventilated adults, and procedural sedation. Propofol is approved for use in more than 50 countries, and has largely replaced sodium thiopental (Pentothal) for induction of GA as the recovery is more rapid and clearer when compared with thiopental. Propofol is not considered an analgesic, so opioids such as fentanyl may be combined with it to alleviate pain. Due to its amnestic effects and appearance as a white liquid, propofol has been humorously dubbed "milk of amnesia” by healthcare workers.

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