Gene Found that Controls Obesity and Sexual Behavior

In a recent study, researchers working with a mouse "knock-out” model have found that the Nhlh2 gene appears to play a role in obesity, physical activity, and sex behavior. The study was published in the December 2002 issue of Physiology and Behavior.

Mice that lack the Nhlh2 gene weigh up to 100 g or more, while most normal mice weigh 25 to 30 grams. The mice eat far past what should be the point of satiety and show little inclination to run on the exercise wheel. They also have smaller genital size and lower sperm counts than typical mice. In addition, the mutant mice show disinterest in mating when they share a cage with a receptive female.

"The gene is responsible for giving them the message, ‘You are full, so stop eating,' or ‘You need to increase your activity, so get some exercise,” explained senior author Deborah J. Good, a researcher at the University of Massachusetts (Amherst, USA ) "Without Nhlh2, the message is sent but can not be received on a molecular level, so their body weight continues to increase.”

"There are humans who have this mutation,” said Dr. Good. "If we understand the molecular mechanisms that deal with obesity, perhaps we will be able to develop pharmaceuticals for people whose enzyme activity is offset. Moreover, humans can be coached to increase their exercise levels and lower their food intake.”




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