Microarray with Rat Biochip with 10,000 Genes

A new microarray with a rat biochip containing 10,000 rat genes, up to now unpublished, allows the functional analysis of a large number of physiologic, biochemical, and biologic correlations.

The microarray, designed for fast and precise identification of disease-relevant genes and the study of drug side effects, enlarges the portfolio of MWG-Biotech AG (Ebersberg, Germany). In addition to the 5,535 genes from public databases already available on the MWG Rat 5K Array, another 4,105 genes were annotated from an in-house sequencing project. In this project, tissue from three different rat strains was sequenced: stroke-prone spontaneously hypertensive rats, wistar Kyoto rats, and Sprague dawley rats. The samples used were taken from brain, heart, liver, and kidney. Called MWG Rat 10 K Array, the array is the newest member of MWG-Biotech's series of catalogue arrays for model organisms.

"In the business unit Genomic Information, we identified new genes by means of EST-sequencing. For these genes, we calculated and produced specific oligonucleotides in our Genomic Synthesis unit, from which the Genomic Diagnosis unit developed and produced the actual array, using bioinformatic tools,” explained Prof. Dr. Matthias Schonermark, CEO of MWG-Biotech.




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