Enhanced Cuvette-Free UV-Visible Spectrophotometer Now Available

The next generation of cuvette-free UV-visible spectrophotometers is now available for biotech and other life science laboratories.

The Thermo Fisher Scientific (Milford, MA, USA) NanoDrop One is the next generation instrument in the NanoDrop series of microvolume UV-visible spectrophotometers and will replace the NanoDrop2000 and 2000C instruments.


NanoDrop spectrophotometers utilize a patented microvolume sample retention system to minimize sample consumption and eliminate the need for cuvettes. A variable, auto-range pathlength feature allows users to measure up to 366 times higher sample concentrations than can be measured in a 10 millimeter cuvette making dilution steps unnecessary. The NanoDrop One does everything that its predecessors can and more, including: on-board instrument control via a touch screen display, a broader dynamic range, expanded connectivity and data management options, and enhanced sample analysis and technical support with Acclaro Sample Intelligence.

Acclaro Sample Intelligence technology enhances user understanding of sample quality while delivering accurate quantitative measurements. There are three parts to Acclaro: (i) data analysis algorithms that provide contaminant identification and corrected concentrations, (ii) an embedded sensor and digital image analysis that monitors the sample column for bubbles to ensure measurement integrity and (iii) sample information alerts and on-demand technical support for guided troubleshooting.

The NanoDrop One instrument boasts Auto-Measure functionality, while advances in communication technology enable results to be shared and archived via Wi-Fi, Ethernet or USB.

“Building on the success of previous NanoDrop instruments, used by thousands of scientists worldwide, we have designed the NanoDrop One instrument to provide simplicity and speed as well as information on sample quality. This allows scientists to accurately quantify and qualify nucleic acid and protein samples, so they can make informed decisions on sample use in downstream applications,” said Dr. Voula Kodoyianni, product manager, molecular spectroscopy at Thermo Fisher Scientific.

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