Improved Optics and Software to Augment a Live-Cell Imaging System

Enhanced hardware and software features have been added to a top-of-the-line live-cell imaging system, which will create new standards for data management.

The Thermo Scientific (Milford, MA, USA) ArrayScan VTI HCS Reader is a modular high content screening (HCS) instrument designed for high-capacity automated fluorescence imaging and quantitative analysis of fixed and live cells. The instrument was designed to provide a platform for researchers to study cellular function in fixed or live cells. High content imaging allows the measurement of events in, on, and around cells over time and has significantly improved drug discovery and systems biology through deeper insights into the understanding of cell functions.

Now, Thermo Fisher has released several new hardware and software enhancements to its flagship Arrayscan VTI HCS Reader. These enhancements are part of the Thermo Scientific High-Content 2.0 program and include the integration of Zeiss (Jena, Germany) Definite Focus hardware into the Arrayscan VTI HCS Reader's live cell configuration. This change is designed to better support high-content analysis of living cells, such as the study of calcium signaling, pharmacokinetics, and toxicity.

This new hardware configuration coupled with Thermo Scientific's existing wide range of kinetic measurement tools, offers researchers increased flexibility and the ability to investigate myriad cellular processes in live cells.

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