First DNA Molecule Constructed Almost Exclusively of Synthetic parts

Japanese chemists have reported the development of the world's first DNA molecule made almost entirely of artificial parts. This finding could lead to improvements in gene therapy, futuristic nanocomputers, and other high-tech developments.

In the new study, which appeared in the July 23, 2008, issue of the Journal of the American Chemical Society, Masahiko Inouye, Ph.D., and colleagues from the University of Toyama (Toyama, Japan) pointed out that scientists have tried for years to develop synthetic versions of DNA in order to extend its remarkable data storage capabilities. As the genetic blueprint of all life forms, DNA uses the same set of four basic building blocks, to code for a variety of proteins used in cell functioning and development. Until now, scientists have only been able to construct DNA molecules with one or a few artificial parts, including specific bases.

The researchers utilized advanced DNA synthesis equipment to bind together four entirely new, artificial bases inside the sugar-based framework of a DNA molecule. This resulted in unusually stable, double-stranded structures resembling natural DNA. Similar to natural DNA, the new structures were right-handed and some easily formed triple-stranded structures. The unique chemistry of these structures and their high stability, according to the researchers, offer unprecedented possibilities for developing new biotech materials and applications.


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