SNP Genotyping Platform Accurately Identifies Rare Donor Blood Types

A single nucleotide polymorphism (SNP) genotyping platform enables faster screening for accurate identification of rare donor blood types.

There are many antigens located on the outer surface of the erythrocyte. Combinations of these blood group antigens vary between individuals even within the same A, B, or O blood type. The specificity of the antibodies in a recipient's blood and the prevalence of antigens in the donor population complicate the task of locating appropriate donors.

The OpenArray SNP genotyping platform, based on through-hole nanoliter fluidics technology, allows scientists to conduct up to 3,072 independent polymerase chain reaction (PCR) analyses simultaneously on a thin metal plate the size of a microscope slide. Developed by BioTrove (Woburn, MA, USA) the genotyping platform expands the capabilities of PCR.

BioTrove Inc. and BloodCenter of Wisconsin (Milwaukee, WI, USA) are collaborating to develop single SNP genotyping as a screening tool for identification of better-matched blood for transfusion. They will use the BioTrove OpenArray system to conduct erythrocyte genotyping more quickly and more economically. BloodCenter of Wisconsin will be able to stratify blood donors based on genotypic characteristics, improving the speed and accuracy of blood transfusions for patients in need.

BloodCenter's diagnostic laboratories develop and perform highly specialized tests on patient samples from throughout the United States and the world. The specialized testing and medical consultation provided by the diagnostic laboratories benefit patients in need of bone marrow or organ transplants, patients with bleeding and clotting disorders, and patients with immunologic, neoplastic, or genetic diseases.


Related Links:
BioTrove
BloodCenter of Wisconsin