Antigen Cocktail Protects Mice from Staph Infection
By Biotechdaily staff writers
Posted on 14 Nov 2006
Researchers have found that immunization with a mixture of four Staphylococcus aureus surface proteins protected a group of laboratory mice from infection by a lethal S aureus strain.Posted on 14 Nov 2006
Investigators at the University of Chicago (Illinois, USA) used available genome sequencing and analysis of antigenic proteins from various S aureus strains to isolate 19 different surface proteins. The four most antigenically potent proteins were injected either singly or in combination into a population of laboratory mice.
Results published in the October 30, 2006, online edition of the Proceedings of the [U.S.] National Academy of Sciences revealed that vaccination with a mixture of the four proteins provided significant protection against challenge with a virulent strain of S aureus. Vaccination with only one of the S aureus proteins failed to trigger a protective immune response.
Senior author Dr. Olaf Schneewind, professor of microbiology at the University of Chicago, said, "When we challenged the immunized mice by exposing them to a human strain of S aureus, the combination vaccine provided complete protection, whereas the control group developed bacterial abscesses.”
Related Links:
University of Chicago
Gold Member
Hematology Analyzer
Medonic M32B
8-Channel Pipette
SAPPHIRE 20–300 µL
 Analyzer.jpg)
CBM Analyzer
Complete Blood Morphology (CBM) Analyzer
