Alliance to Develop New Modules for Live Cell Imaging

A collaboration to develop innovative new fluorescence-detection modules for integration with the Cell-IQ live-cell culturing and analysis system of Chip-Man Technologies Ltd. (Tampere, Finland) has been announced by the company and by ArcDia Ltd. (Turku, Finland).

The new modules will be a first in live-cell imaging, enabling simultaneous measurement and analysis of cell events using both phase contrast and living dyes within the same culture under incubation.

Juha Korpinen, CEO, Chip-Man Technologies, said, "This development will greatly enhance the capabilities of the Cell-IQ to enable even more detailed information to be extracted from living cells. Professors Erkki Soini, Juhani Soini, and colleagues are widely respected in the field of fluorescence detection. We are very fortunate to have such key expertise available within our local academic institutions.”

Cell-IQ represents a major breakthrough in cell analysis by enabling real time monitoring of all morphologic and physiologic changes in cell lines, primary cells, co-cultures and monolayer tissue models. The Cell-IQ software "learns” to recognize and record cellular change and to output these results as real-time moving images and simple multi-parameter graphics.

The addition of a fluorescence detection module will enable the Cell IQ to identify specific siRNA and cDNA transcripts. This will allow them to be closely monitored and the resulting morphologic changes recorded within the population. Thus the measurement of the true rate of cellular stimulation to specific drugs will be possible. In addition researchers can select out those fluorophores that minimally affect cells or have a synergistic or antagonistic effect on target drugs, enabling better optimization and control of cell based experimentation.



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