Novel Nucleic Acid Labeling Kits

New PlatinumBright nucleic acid labeling kits offer a proprietary ULS (universal linkage system) labeling molecule bound to a choice of fluorescent dyes or haptens, for use in fluorescence in situ hybridization (FISH) applications.

The complete labeling kits include unique purification columns that ensure the complete removal of unreacted dye while yielding very high sample recovery, independent of fragment length. The ULS has been engineered to provide very reproducible labeling densities, both inter- and intra-experimental protocols, without the use of enzymes that can cause biases. While designed for FISH applications, the labeling reaction can also be used in Northern blot, Southern blot, spot blot, and dot blot hybridizations as well as with tissue arrays.

ULS labeling of nucleic acids is a one-step procedure that takes only 30 minutes. "End users using PlatinumBright kits can now very easily, quickly, and reproducibly label nucleic acids for whatever application they can think of,” observed Brent Keller, general manager/vice president, commercial operations, for Kreatech Biotechnology B.V. (Amsterdam, The Netherlands; www.kreatech.com). Earlier this year, the company also launched a line of labeling kits with the same dye pairs for the direct labeling of genomic DNA for microarray-based comparative genomic hybridization analysis.






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