Compound Prevents Breast Cancer in Mice
By Biotechdaily staff writers
Posted on 08 Nov 2004
A new compound developed through the combined use of chemistry, biology, bioinformatics, pharmacology, and mathematics has been shown capable of preventing breast cancer in mice.Posted on 08 Nov 2004
The compound was developed by researchers at Parker Hughes (Roseville, MN, USA). Called Compound 003, the compound prolonged cancer-free survival in transgenic mice that otherwise invariably develop HER2-positive metastatic breast cancer. The compound is a novel cytotoxic nucleoside analog and was well tolerated in both mice and rats without toxicity.
The research results were published in the November 2004 issue of the international medical journal Arzneimittelforschung. Women with HER2-positive breast cancer have a greater risk for recurrence of their breast cancer and an increased risk of mortality. Roughly 40,000 women in the United States alone die each year from breast cancer.
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